Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children MIS-C
Bellos, Evangelos and 97 others
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic...
Highlights
BTNL3 binds directly and specifically to Vγ4+ TCRs via its IgV domain
The superantigen-like binding mode focuses on germline-encoded TCR regions
In contrast, γδ TCR binding to a clonally restricted antigen is CDR3-mediated
Mutagenesis indicates parallels with BTN3A1-mediated...
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.