complement

  1. hotblack

    Review Mechanisms of resistance to daratumumab in patients with multiple myeloma, 2024, Iversen

    Mechanisms of resistance to daratumumab in patients with multiple myeloma Iversen KF Abstract Multiple myeloma (MM) is an incurable cancer in the bone marrow. The treatment of MM has developed significantly during the last 20 years, which has resulted in increased survival. Daratumumab is the...
  2. Chandelier

    Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology, 2025, Griggs et al.

    https://academic.oup.com/immunohorizons/article/9/10/vlaf044/8256436?login=false Abstract Hypermobile Ehlers–Danlos Syndrome (hEDS) is a poorly understood connective tissue disorder that lacks molecular diagnostic markers. This study aimed to identify proteomic signatures associated with...
  3. SNT Gatchaman

    The role of complement in long COVID pathogenesis, 2025, Bayarri-Olmos et al.

    The role of complement in long COVID pathogenesis Rafael Bayarri-Olmos; William Bain; Akiko Iwasaki Long COVID is a debilitating condition that can develop after a SARS-CoV-2 infection and is characterized by a wide range of chronic symptoms, including weakness, neurocognitive impairment...
  4. SNT Gatchaman

    Heightened innate immunity may trigger chronic inflammation, fatigue and [PEM]…, 2025, Che, Hornig, Bateman, Klimas, Komaroff, Lipkin+

    Link to published paper here Preprint: Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive...
    • SNT Gatchaman
    • Thread
    • amino acids calcium complement copper extracellular matrix fatty acid metabolism fatty acid oxidation gdf15 gut microbiome herv innate immune system integrins interferon gamma kynurenine lipid metabolism lipids metabolism serotonin tryptophan vegf
    • Replies: 38
    • Forum: ME/CFS research
  5. SNT Gatchaman

    Preprint Molecular Insights into Long COVID: Plasma Proteomics Reveals Oxidative Stress, Coagulation Cascade Activation & Glycolytic Imbalance,2025,Ramanathan+

    Molecular Insights into Long COVID: Plasma Proteomics Reveals Oxidative Stress, Coagulation Cascade Activation, and Glycolytic Imbalance Sheela Ramanathan; Mohammad Mobarak Hussain Chowdhury; Akouavi Julite Irmin Quenum; Christine Rioux-Perreault; Jean-Francois Lucier; Subburaj Ilangumaran...
    • SNT Gatchaman
    • Thread
    • coagulation complement glutathione oxidative stress paraoxonase 3 peroxiredoxin pon3 prdx6 proteomics
    • Replies: 1
    • Forum: Long Covid research
  6. SNT Gatchaman

    Is COVID-19 Coagulopathy a Thrombotic Microangiopathy? A Prospective, Observational Study, 2025, Silingardi et al.

    Is COVID-19 Coagulopathy a Thrombotic Microangiopathy? A Prospective, Observational Study Silingardi, Mauro; Zappulo, Fulvia; Dormi, Ada; Pizzini, Attilia Maria; Donadei, Chiara; Cappuccilli, Maria; Fantoni, Chiara; Zaccaroni, Stefania; Pizzuti, Valeria; Cilloni, Nicola; Tantillo, Simona; Guidi...
  7. forestglip

    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson [Line...
    • forestglip
    • Thread
    • complement endoplasmic reticulum energy metabolism extracellular vesicles giloteaux glass maureen hanson prdx6 study idea
    • Replies: 57
    • Forum: ME/CFS research
  8. SNT Gatchaman

    Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

    Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad; Hans-Peter Marti; Olav Mella; Oystein...
    • SNT Gatchaman
    • Thread
    • bone marrow capillaries coagulation complement endothelium ephrin fgf21 fluge gdf15 hif-1 histone hypoxia leptin mcts1 mella myeloperoxidase myoglobin neutrophils pxdn sex differences
    • Replies: 68
    • Forum: ME/CFS research
  9. SNT Gatchaman

    Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development, 2025, Dobra et al.

    Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development Dobra; Gyukity-Sebestyen; Bukva; Boroczky; Nyiraty; Bordacs; Varkonyi; Kocsis; Szabo; Kecskemeti; Polgar; Szell; Buzas Post-COVID syndrome affects 10–35 % of COVID-19 patients, and up to 85 % of...
  10. SNT Gatchaman

    Preprint Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection…, 2025, Holmqvist+

    Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study Madlene Holmqvist; Dick J Sjöström; Katherine Carlson; Birgitta Gullstrand; Anders A Bengtsson; Robin Kahn; Tom E Mollnes; Per Åkesson; Per H Nilsson; Fredrik...
  11. SNT Gatchaman

    Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients…, 2025, Liu+

    Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19 Jiangfeng Liu; Li Guo; Jingchuan Zhong; Yue Wu; Xinming Wang; Xiaoyue Tang; Kaiyuan Min; Yehong Yang; Wanjun Peng; Qiaochu Wang; Tao Ding; Xiaoying...
  12. forestglip

    [...] serum and peritoneal fluid [MBL] associated serine protease-3, adipsin, properdin, and [CFH] levels in endometriosis patients, 2025, Tanrıverdi+

    Evaluation of serum and peritoneal fluid mannose-binding lectin associated serine protease-3, adipsin, properdin, and complement factor-H levels in endometriosis patients Merve Didem Eşkin Tanrıverdi, Ecem Kaya Sezginer, Esin Merve Erol Koç, Özlem Moraloğlu Tekin Objective Endometriosis is a...
  13. SNT Gatchaman

    CspZ variant–specific interaction with factor H incorporates a metal site to support Lyme borreliae complement evasion, 2024,Brangulis+

    CspZ variant–specific interaction with factor H incorporates a metal site to support Lyme borreliae complement evasion Kalvis Brangulis; Valerie Sürth; Ashley L. Marcinkiewicz; Inara Akopjana; Andris Kazaks; Janis Bogans; Alisa Huber; Yi-Pin Lin; Peter Kraiczy Polymorphic microbial immune...
  14. Nightsong

    Association of high complement and low immunoglobulins with the clinical symptoms of patients with fibromyalgia, 2025, Izuno+

    Background Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with various symptoms such as fatigue and anxiety. Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and...
  15. SNT Gatchaman

    Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells, 2024, Gultom et al.

    Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells Gultom, Mitra; Lin, Lin; Brandt, Camilla Blunk; Milusev, Anastasia; Despont, Alain; Shaw, Jane; Döring, Yvonne; Luo, Yonglun; Rieben, Robert Severe acute respiratory syndrome coronavirus 2...
    • SNT Gatchaman
    • Thread
    • coagulation complement endothelial cells endothelial dysfunction spike protein tnf vascular
    • Replies: 0
    • Forum: Long Covid research
  16. forestglip

    Preprint Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19, 2024, Wei et al

    Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19 Yulin Wei, Hongyan Gu, Jun Ma, Xiaojuan Mao, Bing Wang, Weiyan Wu, Shimin Yu, Jinyuan Wang, Huan Zhao, yanbin he [Preprint] Abstract Long COVID is an often-debilitating condition with...
    • forestglip
    • Thread
    • arachidonic acid coagulation complement complement system fatty acid metabolism glycerophospholipids gnai2 gpcr lipid metabolism long covid metabolomics platelets proteomics sphingolipids thrombospondin-1 transport tsp-1 tsp1
    • Replies: 10
    • Forum: Long Covid research
  17. forestglip

    Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions, 2024, Seco-González et al

    Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions Alejandro Seco-González, Paula Antelo-Riveiro, Susana B. Bravo, P.F. Garrido, M.J. Domínguez-Santalla, E. Rodríguez-Ruiz, Á. Piñeiro, R. Garcia-Fandino Background Persistent symptoms extending beyond...
    • forestglip
    • Thread
    • antimicrobial peptides coagulation complement complement system cytoskeleton glycolysis immune system long covid oxidative stress proteomics
    • Replies: 15
    • Forum: Long Covid research
  18. forestglip

    Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome, 2015, Rajeevan et al

    2015 study Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome Mangalathu S. Rajeevan, Irina Dimulescu, Janna Murray 1, Virginia R. Falkenberg, Elizabeth R. Unger Abstract Recent evidence suggests immune and inflammatory alterations are...
    • forestglip
    • Thread
    • chemokines complement complement factor h complement system cytokines factor h il18 serpina5
    • Replies: 6
    • Forum: ME/CFS research
  19. Yann04

    [Preprint] Unravelling the Impact of SARS-CoV-2 on Hemostatic and Complement Systems: A Systems Immunology Perspective, 2024, Murad et al

    Abstract: The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been...
  20. SNT Gatchaman

    Long-term dysregulation of plasma peptidome in mild and multiple COVID-19 recovered patients revealed by a novel peptidomics workflow, 2024, Song+

    Long-term dysregulation of plasma peptidome in mild and multiple COVID-19 recovered patients revealed by a novel efficient peptidomics workflow Song, Zhijing; Liu, Chaoran; Liu, Yaozhou; Bian, Zheng; Sun, Qing; He, Ting; Su, Rong; Huang, Shengchun; Dai, Ningbin; Zhao, Ke li; Li, Yan; Liang, Kai...
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