damps

  1. Mij

    Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal, 2024, Laura E. Newman et al

    Abstract Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not...
  2. Andy

    Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren’s syndrome, 2021, Barrera et al

    Highlights • Chronic inflammation can be caused by organelle (e.g., mitochondria) malfunction. • Dysfunctional mitochondria release DAMPs that trigger inflammation through PRRs. • Salivary cells’ mitochondria show ultrastructural alterations in Sjögren’s syndrome. • Endoplasmic reticulum...
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