damps

Metabolism and Innate Immunity Meet at the Mitochondria Bahat, A., MacVicar, T., & Langer, T Abstract Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation...

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C Abstract The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell...

Abstract Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not...

Highlights • Chronic inflammation can be caused by organelle (e.g., mitochondria) malfunction. • Dysfunctional mitochondria release DAMPs that trigger inflammation through PRRs. • Salivary cells’ mitochondria show ultrastructural alterations in Sjögren’s syndrome. • Endoplasmic reticulum...