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https://neuroimmune.cornell.edu/research/participant-interactions/ Participant Interactions We are seeking volunteers comprising 40 ME/CFS patients and 20 controls to participate in this NIH funded (U54AI178855) project. The ME/CFS subjects will be identified by expert physician Dr. Susan...

Background Post-acute COVID-19 syndrome (PACS) has been linked to microvascular endothelial dysfunction as a potential underlying pathomechanism and can manifest even following a mild course of the initial infection. Prevalence of microvascular endothelial dysfunction and circulating natriuretic...

Preprint Link to published paper here ** The Lancet: Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated B2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study Abstract Background: Since the pandemic, SARS-CoV-2 has become the leading trigger for ME/CFS...

Sex Modifies the Effect of COVID-19 on Arterial Elasticity Durieux, Jared C.; Zisis, Sokratis N.; Mouchati, Christian; Labbato, Danielle; Abboud, Marc; McComsey, Grace A. There is limited long-term evidence on the effects of COVID-19 on vascular injury between male and female sex. An adult...

Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID. Lucie Rodriguez; Ziyang Tan; Lakshmi Kanth Tadepally; Jun Wang; Hugo Barcenilla; Zoe Swank; Fanglei Zuo; Hassan Abolhassani; Ana Jimena Pavlovitch-Bedzyk; Chunlin Wang...

Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children Julie Boever; Claudia Nussbaum; Leonie Arnold; Nikolaus A. Haas; Simone K. Dold; Felix S. Oberhoffer; André Jakob No Abstract. Videos of sublingual microcirculation were obtained with a handheld MicroScan video...

Arterial Stiffness and Oxidized LDL Independently Associated With Post-Acute Sequalae of SARS-CoV-2 Sokratis Zisis; Jared Durieux; Christian Mouchati; Nicholas Funderburg; Kate Ailstock; Mary Chong; Danielle Labbato; Grace McComsey Objectives COVID-19 survivors can experience lingering symptoms...

Does anyone know more about this study? From the description it sounds as if the change in endothelial function is seen quickly, unlike the 2-day CPET where a delay of 24 hours is required to see changes on the second test. This would make repeated EndoPET with exercise in between a superior...

We are conducting a study on endothelial function, upright activity and cognition in ME/CFS and Long Covid and collecting blood samples to assess for biomarkers. The study will require a 2-hour in-person visit and then will continue for seven days with tests and surveys that are done from the...

Women are more prone to orthostatic intolerance compared to men and have a greater vasodilatory capacity. We investigated the hypothesis that women would have greater peripheral flow-mediated dilation (FMD) while in the upright posture compared to men, which could contribute to this phenomenon...

Transl Med Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Milan Haffke et al Abstract Background: Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of...