gastrointestinal

Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients Johanna Rohrhofer; Viktoria Wolflehner; Johannes Schweighardt; Larissa Koidl; Michael Stingl; Sonja Zehetmayer; Joana Séneca; Petra Pjevac; Eva Untersmayr BACKGROUND Post-COVID Syndrome (PCS) is the term for a condition...

Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling Yuanheng Yang; Cong Hao; Tingying Jiao; Zidan Yang; Hui Li; Yuqing Zhang; Weiya Zhang; Michael Doherty; Chuying Sun; Tuo Yang; Jiatian Li; Jing Wu; Mengjiao Zhang; Yilun Wang; Dongxing Xie; Tingjian...

Pediatric Gastrointestinal Tract Outcomes During the Postacute Phase of COVID-19 Dazheng Zhang et 84 al. for the Researching COVID to Enhance Recovery (RECOVER) Initiative IMPORTANCE The profile of gastrointestinal (GI) tract outcomes associated with the postacute and chronic phases of COVID-19...

New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx Changela, Sagar; Ashraf, Samad; Lu, Justin Y. ; Duong, Kevin E. ; Henry, Sonya; Wang, Stephen H. ; Duong, Tim Q. This study examined the incidence, characteristics, and...

Organ-specific sympathetic innervation defines visceral functions Wang, Tongtong; Teng, Bochuan; Yao, Dickson R.; Gao, Wei; Oka, Yuki The autonomic nervous system orchestrates the functions of the brain and body through the sympathetic and parasympathetic pathways1 . However, our understanding...

Gastrointestinal manifestations of long COVID Louise R. King Abstract Long COVID is estimated to have affected 6.9 % of US adults, 17.8 million people in the US alone, as of early 2023. While SARS-CoV-2 is primarily considered a respiratory virus, gastrointestinal (GI) symptoms are also...

Neuro-intestinal acetylcholine signalling regulates the mitochondrial stress response in Caenorhabditis elegans Cornell, Rebecca; Cao, Wei; Harradine, Bernie; Godini, Rasoul; Handley, Ava; Pocock, Roger Neurons coordinate inter-tissue protein homeostasis to systemically manage cytotoxic stress...

An article in The Canary (Nicola Jeffrey 2024) said: Dumping Syndrome may also be referrered to as reactive hypoglycemia, postprandial hypoglycemia, or rapid gastric emptying however some of those appear to be features of Dumping Syndrome rather than an alternative name. This article...

https://www.explorationpub.com/uploads/Article/A1001215/1001215.pdf Abstract Aim: It is unclear if individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with family histories of ME/CFS differ from those with ME/CFS without this family history. To explore this issue...

Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management Fei Yang; Yeda Wu; Richard Hockey; Jenny Doust; Gita D. Mishra; Grant W. Montgomery; Sally Mortlock In clinical practice, the co-existence of...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection IMPORTANCE SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as...

Abstract This multicenter cohort study used Sankey plots and exponential bar plots to visualize the fluctuating evolution and the trajectory of gastrointestinal symptoms in previously hospitalized COVID-19 survivors during the first 18 months after acute SARS-CoV-2 infection. A total of 1266...

I recieved a SIBO diagnosis recently which is recognised as causing IBS and is linked to traumatic injury in some cases as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347643/#:~:text=The%20pathogenesis%20of%20irritable%20bowel,SIBO)%2C%20causes%20IBS%20symptoms...

https://www.cell.com/med/fulltext/S2666-6340(22)00167-2 Highlights 1.Approximately half of COVID-19 patients shed fecal RNA in the week after infection 2. 4% patients with COVID-19 shed fecal viral RNA 10 months after diagnosis. 3. Presence of fecal SARS-CoV-2 RNA is associated with...

Abstract Background: About 10% of individuals who contract infectious mononucleosis (IM) have symptoms 6 months later that meet criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study for the first time examined whether it is possible to predict who will develop...

Highlights Genetics of gut motility via data on stool frequency in 167,875 individuals GWAS identifies 14 loci associated with stool frequency Candidate genes enriched in neurotransmitter signaling and enteric motor neurons Polygenic scores predict increased risk of irritable bowel syndrome...

Abstract Functional Gastrointestinal Disorders (FGID) are Disorders of Gut-Brain Interaction (DGBI) recognized by a variety of symptoms caused by abnormalities within gastrointestinal (GI) motility, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and...

This survey study, nested within a prospective cohort of COVID-19 survivors with a minimum of 6 months of follow-up time, assessed the hypothesis that mental health symptoms both preceding and following COVID-19 infection would be associated with post-COVID chronic GI symptoms (see Methods...

Abstract Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that...