glycolysis

Now published - link to post Preprint Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 Postural Orthostatic Tachycardia Syndrome PC-POTS patients Taekyung Ryu; Brit Adler; Seeun Judy Jeong; David C. Lee; Tae Hwan Chung Postural orthostatic tachycardia syndrome...

Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions Alejandro Seco-González, Paula Antelo-Riveiro, Susana B. Bravo, P.F. Garrido, M.J. Domínguez-Santalla, E. Rodríguez-Ruiz, Á. Piñeiro, R. Garcia-Fandino Background Persistent symptoms extending beyond...

SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...

Redefining the role of Hypoxia-inducible factors HIFs in oxygen homeostasis Clemente Fernández Arias; Franciso J Acosta; Federica Bertocchini; Cristina Fernández-Arias Hypoxia-inducible factors (HIFs) are key regulators of intracellular oxygen homeostasis. The marked increase in HIFs activity...

Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time Giuseppe Gianini Figueirêdo Leite; Milena Karina Colo Brunialti; Paula M. Peçanha-Pietrobom; Paulo R. Abrão Ferreira; Jaquelina Sonoe Ota-Arakaki; Edecio...

Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia Francesca Sciarretta; Fabio Zaccaria; Andrea Ninni; Veronica Ceci; Riccardo Turchi; Savina Apolloni; Valerio Chiurchiu; Marta Tiberi; Nadia D'Ambrosi; Silvia...

Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and pathological processes. However, whether lactate regulates autophagy is still unknown. We recently reported that LDHA is phosphorylated at serine 196 by...

Role of miR-2392 in driving SARS-CoV-2 infection J. Tyson McDonald; Francisco J. Enguita; Deanne Taylor; Robert J. Griffin; Waldemar Priebe; Mark R. Emmett; Mohammad M. Sajadi; Anthony D. Harris; Jean Clement; Joseph M. Dybas; Nukhet Aykin-Burns; Joseph W. Guarnieri; Larry N. Singh; Peter...

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts Joseph W. Guarnieri; Joseph M. Dybas; Hossein Fazelinia; Man S. Kim; Justin Frere; Yuanchao Zhang; Yentli Soto Albrecht; Deborah G. Murdock; Alessia Angelin; Larry N. Singh; Scott L. Weiss; Sonja M...

Abstract Previous studies have shown that monocytes can be ‘trained’ or tolerized by certain stimuli to respond stronger or weaker to a secondary stimulation. Rewiring of glucose metabolism was found to be important in inducing this phenotype. As we previously found that Borrelia burgdorferi...

Abstract Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus (H1N1), a single-stranded, negative-sense RNA virus with an eight-segmented genome, enhanced glycolysis...

https://www.mdpi.com/1422-0067/22/4/2046

Summary Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many organisms and conditions. To better understand that association, we examined the metabolic consequence of activating the pyruvate...

So there is some evidence for impairment of glycolysis in pwME, leading to use of other fuel sources. I'm curious as to what the practical implications of this impairment on glucose itself (if anybody knows). If glycolysis is impaired, does it meant that glucose is used up at the same rate as...

Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext

Open access, https://www.biorxiv.org/content/10.1101/2020.09.22.308171v1.full-text

Basal glycolysis is reduced in ME/CFS CD4+ T cells. https://www.jci.org/articles/view/132185/figure/4 paper from December 2019 https://www.jci.org/articles/view/132185 new Article by Mady Hornig https://www.jci.org/articles/view/134985

I decided to start this thread based on the latest findings of the Whole Genome Sequencing webinar from SolveCFS. During the seminar a slide was shown related to Glycogen Storage Diseases -there are 14 types- and a specific mention was about GSD Type 13 for Enolase beta. I decided to start...

https://www.ncbi.nlm.nih.gov/pubmed/29981562 The DOI (digital object identifier, aka ID number) for this doesn't seem to work, so I'm not sure anything beyond the abstract has been published yet.

The article, https://phys.org/news/2018-05-lactate-poison.amp The paper, https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30186-4? Full paper here, http://sci-hub.tw/10.1016/j.cmet.2018.03.008