hdac

  1. SNT Gatchaman

    Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function, 2025, Folkerts et al.

    Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function Jelle Folkerts; Marjolein J. W. de Bruijn; Wilfred F. J. van IJcken; Rudi W. Hendriks; Ralph Stadhouders Mast cells are key drivers of allergic inflammation. We have previously...
  2. Mij

    Butyrate enhances CD56 NK cell-driven killing of activated T cells and modulates NK cell chromatin accessibility, 2025, Federico Carlini et al

    Abstract Gut bacteria-derived metabolites, such as butyrate (BUT), induce T regulatory cells through inhibition of histone deacetylases (HDAC). Natural killer (NK) cells are innate lymphocytes with important effector and regulatory functions; little is known on the effect of BUT on NK cells...
  3. forestglip

    Preprint Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID, 2025, Le et al

    Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID Thuc Duy Le, Sindy Licette Pinero, Xiaomei Li, Lin Liu, Jiuyong Li, Sang Hong Lee, Marnie Winter, Thin Nguyen, Junpeng Zhang Background Long COVID, or Post–Acute Sequelae of COVID–19 (PASC), involves persistent...
    • forestglip
    • Thread
    • ceramide fyn genetics hdac lipids long covid ndufaf6 p53 smad sphingolipids tgf-beta
    • Replies: 9
    • Forum: Long Covid research
  4. Andy

    Review DNA methylation signatures of functional somatic syndromes: Systematic review, 2023, Fischer et al

    Objective Functional somatic syndromes (FSS) are highly prevalent across all levels of healthcare. The fact that they are characterised by medically unexplained symptoms, such as fatigue and pain, raises the important question of their underlying pathophysiology. Psychosocial stress represents...
    • Andy
    • Thread
    • dna methylation epigenetics hdac hla hla-dqb1
    • Replies: 5
    • Forum: ME/CFS research
  5. John Mac

    Open The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2021 Polli

    Not yet recruiting https://www.medifind.com/conditions/chronic-fatigue-syndrome/1135/clinical-trial/223304133
  6. Andy

    Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases, 2019, McGregor et al

    Open access at https://www.mdpi.com/2075-4418/9/3/70
    • Andy
    • Thread
    • 2019 hdac hypermetabolism hypoacetylation hypoxanthine mcgregor me/cfs paper pem
    • Replies: 92
    • Forum: ME/CFS research
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