Long-COVID Postural Tachycardia Syndrome: A deep phenotyping study
Nicholas W Larsen; Jannika V Machnik; Jordan Seliger; Ruba Shaik; Christopher H Gibbons; Paul J Utz; Maarten G Lansberg; Srikanth Muppidi; Safwan Jaradeh; Mitchell G Miglis
BACKGROUND
Postural tachycardia syndrome (POTS) has...
Highlights
POTS causes cardiovascular instability and severe symptoms.
Postural hyperventilation is thought to cause POTS, but the mechanisms are unclear.
Reduced stroke volume and brain perfusion drive postural hyperventilation in POTS.
Stroke volume and brain perfusion should be targeted as...
Abstract
50% of POTS patients are hypocapnic during orthostasis related to initial orthostatic hypotension (iOH). We determined whether iOH drives hypocapnia in POTS by low BP or decreased cerebral blood flow velocity (CBFv). We studied 3 groups; healthy volunteers (N=32, 18±3y) were compared...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03289-8
Benjamin H. Natelson
Jin-Mann S. Lin
Michelle Blate
Sarah Khan
Yang Chen
Elizabeth R. Unger
Open access
Background
Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue...
To the Editor,
Debilitating symptoms including fatigue, post-exertional malaise, brain fog, weakness, headache and dizziness can persist for over six months in individuals with Long COVID 1,2 (also referred to post-acute COVID-19 syndrome, post-COVID condition or post-acute sequelae of...
Moved post
New video from Medinger. This time in conversation with dr. David Putrino, a British physiotherapist who is the director of rehabilitation innovation at Mt. Sinai in New York and now works with long haulers.
10 minutes in he says he was discussing the symptoms of his Long Covid...
https://doi.org/10.1371/journal.pone.0204419
My take away from this: patients with hypocapnic cerebral hypoperfusion present the same symptoms as patients with POTS but can fail a tilt test due to absence of tachycardia.
ME/CFS is also mentioned.
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