hypothesis

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

New here. An ME blogger suggested I bring this idea here for discussion. Will leave out 9/10ths of this idea, looking to see if there's interest in discussion, and most importantly...facts which make this wrong. There’s a protein called myoglobin. It is expressed on muscle cells. One end of...

Something I've been meaning to work out for a while. For any theoretical model explaining the mechanisms of ME/CFS, there are necessary conditions that must be met, without which a model simply cannot account for the data. What are those? Especially with a purpose to falsify flawed models and...

"About the Patient-Generated Hypotheses Journal Welcome to the Patient-Led Research Collaborative’s first issue of the Patient-Generated Hypotheses Journal. This issue is a compilation of six hypotheses plus poll results. People with Long COVID and associated conditions and caregivers of...

https://www.nature.com/articles/s41584-022-00873-6 Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other symptoms, and has a substantial socioeconomic impact. Current biomedical and psychosocial treatments are unsatisfactory for many patients, and treatment...

Orthostatic Intolerance after COVID-19 Infection: Is Disturbed Microcirculation of the Vasa Vasorum of Capacitance Vessels the Primary Defect? Wirth and Lohn Abstract : Following COVID-19 infection, a substantial proportion of patients suffer from persistent symptoms known as Long COVID. Among...

https://osf.io/ef3n4/ The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...

Edwards JC, McGrath S, Baldwin A, Livingstone M, Kewley A. The biological challenge of myalgic encephalomyelitis/chronic fatigue syndrome: a solvable problem. Fatigue. 2016;4(2):63-69. doi:10.1080/21641846.2016.1160598 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867862/ Abstract Myalgic...

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Dominic Stanculescu, Nuno Sepúlveda, Chin Leong Lim and Jonas Bergquist Abstract We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms...

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul Abstract There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic...

There are some issues and concerns around the IDO2 tryptophan trap hypothesis about ME. These are my current thought directions, and should not be considered scientific fact. Please comment, add links, agree or disagree, or move this post to somewhere better if you are a moderator. Concerns...

Journal link Sci-hub link Personal comment: episodes of paralysis or severe weakness which can be triggered by exertion, heat, cold, or occur upon awakening in the morning, and may improve with carbohydrates and electrolytes are symptom of periodic paralysis, although most people with periodic...

https://www.sciencedirect.com/science/article/abs/pii/S0306987720302437

https://www.vox.com/science-and-health/2018/9/5/17818170/work-fatigue-exhaustion-psychology "This is the greatest mystery of my adult life: How can I spend all day typing at a computer and go home feeling exhausted? How could merely activating the small muscles of my fingers leave me craving...

The link between idiopathic intracranial hypertension, fibromyalgia, and chronic fatigue syndrome: exploration of a shared pathophysiology (This is a hypothesis paper) https://www.dovepress.com/the-link-between-idiopathic-intracranial-hypertension-fibromyalgia-and-peer-reviewed-article-JPR...

Paywalled at https://www.medical-hypotheses.com/article/S0306-9877(18)30364-5/fulltext

OMF-funded research: a metabolic ‘trap’ hypothesis for ME/CFS - Dr. Robert Phair, March 2018 https://www.omf.ngo/2018/03/14/omf-funded-research-a-metabolic-trap-hypothesis-for-me-cfs/ March 14, 2018 On this #OMFScienceWednesday we highlight a new project that OMF is funding, which proposes a...