immune activation

Abstract: The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks1,2,3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The...

Hypocortisolemic ASIA: A vaccine-and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis (Provisionally accepted) Manuel Ruiz-Pablos 1, Aintzane Zabaleta 2, Bruno Paiva 2 1 Complutense University of Madrid, Madrid, Madrid, Spain 2 Center of Applied...

Comparative Cohort Study of Post-Acute Covid-19 Infection with a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome (The COVIVA Study) David Saunders; Thomas B Arnold; Jason M Lavendar; Daoqin Bi; Karl Alcover; Lydia D Hellwig; Sahar T...

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiologic agent of the coronavirus disease 2019 (COVID-19), is now rapidly disseminating throughout the world with 147,443,848 cases reported so far. Around 30–80% of cases (depending on COVID-19 severity) are reported...

BBC article, "The race to understand 'immune amnesia'" ETA: Added link that I originally overlooked to include, and @Arnie Pye kindly sorted for me, but thought I'd better include in this post anyway. https://www.bbc.com/future/article/20211112-the-people-with-immune-amnesia

Lutz L, Rohrhofer J, Zehetmayer S, Stingl M, Untersmayr E. Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Biomolecules. 2021; 11(9):1359. https://doi.org/10.3390/biom11091359 free full text...

Abstract Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to...

*In mice I find it interesting to find the usual "associations" of anxiety, depression and emotions. Seems bloody obvious that it yet again reinforces the fact that those "associations" are all bogus and the product of a poor "diagnostic" process. Though I have no idea how they identify any of...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220254/ Very interesting paper which has identified MYSM1, a part of the ubiquitin system that acts as a molecular switch to deactivate the innate immune system and has the ability to prevent certain diseases caused by an excessive activation of the...

Full blog A team led by Edinburgh University’s Professor Chris Ponting has won funding for a PhD student who would follow up and expand on remarkable recent findings made at Stanford University where Dr Mark Davis may have pinpointed a major issue in the immune system in ME/CFS. Last year...