Summary
A previously healthy 39-year-old man developed highly symptomatic post-COVID-19 condition (also known as long COVID) marked by cognitive dysfunction, disabling fatigue, and autonomic symptoms unresponsive to multiple multidisciplinary interventions. Given the presence of markedly...
Full title: Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss
Abstract
B7 costimulatory family member Butyrophilin 2A2 (BTN2A2) is predominantly expressed by antigen presenting cells and...
Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease
The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other...
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity
The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how near-universal exposure to the same pathogen can lead to either effective or...
Highlights:
• LFA-1 mediated co-stimulation of CD8+ T cells depends on extracellular magnesium
• Magnesium is sensed via LFA-1 and regulates the effector function of CD8+ T cells
• Low serum magnesium levels are associated with worse outcomes in cancer immunotherapy
• The magnesium-LFA-1...
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