Blood diagnostic biomarkers for neurologic manifestations of long COVID
BACKGROUND
SARS-CoV-2 responsible for COVID-19 caused a global pandemic, with billions of infections, millions of deaths and ongoing manifestations post COVID-19. “Long Covid”, a Post-Acute Sequelae of COVID-19 (PASC), is...
Post-COVID syndrome patients show reduced anti-Spike antibodies compared to COVID-recovered controls, but enhanced IgG4/IgG1 switch after the third vaccine dose
INTRODUCTION
Long COVID and post-COVID syndromes represent a significant global health crisis and a substantial societal challenge...
Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis
BACKGROUND AND OBJECTIVES
Intrathecal synthesis of immunoglobulin G (IgG) is a key feature of multiple sclerosis (MS) and a prognostic marker for the disease course. Although previous...
Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID
Long COVID (LC) is a post-acute infection syndrome affecting 5%–10% of individuals infected by SARS-CoV-2. Here, we aimed to study SARS-CoV-2 humoral immunity, immunological...
Abstract:
Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients' sera into mice induces some clinical features of PASC. IgG-induced...
Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection
Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children...
The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells
Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism...
Protective role of anti-SARS-CoV-2 antibody responses against vital organ related long COVID symptoms
Yukari Magawa, Jhosiene; Jacintho, Lucas Cauê; Alves Ferreira, Marcelo; Ramos Oliveira, Jamille; Rahal Guaragna Machado, Rafael; Kuramoto Takara, Andreia; Moreno Lima de Oliveira, Renata...
Full title:
The Effect on Quality of Life of Therapeutic Plasmapheresis and Intravenous Immunoglobulins on a Population of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated β-Adrenergic and M3-Muscarinic Receptor Antibodies—A Pilot Study...
SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole
Petry; Shoykhet; Weiser; Griesbaum; Bashiri Dezfouli; Verschoor; Wollenberg
COVID-19 patients face an increased risk of thromboembolic complications, yet the exact pathophysiological role of platelets...
Immunotherapies for Postural Orthostatic Tachycardia Syndrome, Other Common Autonomic Disorders and Long COVID: Current State and Future Direction
Blitshteyn, S., Funez-dePagnier, G., Szombathy, A., & Hutchinson, M
Abstract
Postural orthostatic tachycardia syndrome (POTS), neurocardiogenic...
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures
Huanhuan Li; Minh C. Pham; Jinfeng Teng; Kevin C. O’Connor; Colleen M. Noviello; Ryan E. Hibbs
Skeletal muscle contraction is triggered by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at...
Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19
Jiangfeng Liu; Li Guo; Jingchuan Zhong; Yue Wu; Xinming Wang; Xiaoyue Tang; Kaiyuan Min; Yehong Yang; Wanjun Peng; Qiaochu Wang; Tao Ding; Xiaoying...
Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies
Cole Maguire; Kristina Kashyap; Elizabeth Williams; Aziz Rija; Maisey Schuler; Cheyenne Ahamed; Chumeng Wang; Aurelia Mena; Jeffrey Saniuk; Johanna Busch; Sara Austin; Mary Kelley...
Proteomics Reveals That Vitamin D Deficiency Leads to Immunoglobulin Abnormalities and Immune Dysregulation in Patients with Post-COVID-19 Condition
Wenrui Ji; Xiaomin Xie; Guirong Bai; Yalei Fan; Yanting He; Li Zhang; Haiyan Zhou; Ling Li; Huan Li
Vitamin D (VD) levels are closely related to...
ACE-2-like Enzymatic Activity in COVID-19 Convalescent Patients with Persistent Pulmonary Symptoms Associated with Immunoglobulin
Yufeng Song; Frances Mehl; Lyndsey M. Muehling; Glenda Canderan; Kyle Enfield; Jie Sun; Michael Yin; Sarah J. Ratcliffe; Jeffrey M Wilson; Alexandra Kadl; Judith A...
Background
Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with various symptoms such as fatigue and anxiety. Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and...
High Somatization Rates, Frequent Spontaneous Recovery, and a Lack of Organic Biomarkers in Post-Covid-19 Condition
Anna Tröscher; Patrick Gebetsroither; Marc Rindler; Vincent Böhm; Rainer Dormann; Tim von Oertzen; Anna Heidbreder; Raimund Helbok; Judith Wagner
INTRODUCTION
Many patients report...
Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in Children
Jacob D. Sherman; Vinit Karmali; Bhoj Kumar; Trevor W. Simon; Sarah Bechnak; Anusha Panjwani; Caroline R. Ciric; Dongli Wang; Chris Huerta; Brandi...
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