insulin resistance

Abstract: Objectives Exercise capacity is decreased in diabetes mellitus due to impaired insulin sensitivity, endothelial dysfunction and mitochondrial dysfunction. The aim of the study was to evaluate the effect of metformin on exercise capacity in treatment naïve patients with type 2 diabetes...

Proteolethargy is a pathogenic mechanism in chronic disease Alessandra Dall’Agnese; Ming M. Zheng; Shannon Moreno; Jesse M. Platt; An T. Hoang; Deepti Kannan; Giuseppe Dall’Agnese; Kalon J. Overholt; Ido Sagi; Nancy M. Hannett; Hailey Erb; Olivia Corradin; Arup K. Chakraborty; Tong Ihn Lee...

Endometriosis Patients Have an Increased Risk of Experiencing Long-Covid Symptoms: Results from a Cross-Sectional Multicenter Study Anna Cirkel; Hartmut Göbel; Carl Göbel; Ibrahim Alkatout; Ahmed Khalil; Sascha Baum; Norbert Brüggemann; Achim Rody; Christoph Cirkel BACKGROUND Women are more at...

After the really interesting recent study by @Chris Ponting showing some markers of insulin resistance in ME patients, the question arises, why would the HbA1c not be indicating insulin resistance in these patients? I have seen Continuous Glucose Monitor (CGM) charts of people with ME, and...

I bought a continuous glucose monitor a while ago thinking it could be interesting to try. @TamaraRC 's post has inspired to me to finally put it on. Here's a trace from when I had 5 pieces of a medium pizza yesterday evening (peak on the right): and a relative of mine eating exactly the...

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

Abstract Myalgic Encephalomyelitis (ME; sometimes referred to as chronic fatigue syndrome) is a relatively common and female-biased disease of unknown pathogenesis that profoundly decreases patients' health-related quality-of-life. ME diagnosis is hindered by the absence of robustly-defined and...