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Highlights
• Viruses induce depressive behavior and ISG15 expression at the blood-brain barrier
• IFNAR1 expression on neural cells is not involved in IFN-β-induced sickness behavior
• IFNAR1 expression on brain endothelial and epithelial cells drives behavioral changes
• Brain...
Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation
Interferon-stimulated gene 15 (ISG15) regulates diverse cellular responses including antiviral immunity through its conjugation to proteins, a process known as ISGylation. Several pathogens, including...
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