jak-stat

  1. forestglip

    [Transcriptome] in PBMCs of [LC] at a median follow-up of 28 months [...] reveals upregulation of JAK/STAT [...], 2025, Fineschi et al

    Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
    • forestglip
    • Thread
    • annexin atp haemoglobin histone il-9 interferon jak-stat lactate long covid mitochochria mitochondrial dysfunction neutrophils oxidative phosphorylation ubiquitination
    • Replies: 19
    • Forum: Long Covid research
  2. SNT Gatchaman

    Review Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Syed, Karius, Wang, Hwang

    Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...
    • SNT Gatchaman
    • Thread
    • actin atp eif2a endoplasmic reticulum er stress interferon jak-stat mitochochria mitochondrial dysfunction nf-κb wasf3
    • Replies: 15
    • Forum: ME/CFS research
  3. SNT Gatchaman

    Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Monocytes, Avoiding [LC], 2025, Olivares-Martínez+

    Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID Olivares-Martínez, Elizabeth; Hernández-Ramírez, Diego Francisco; Núñez-Álvarez, Carlos Alberto; Meza-Sánchez, David Eduardo; Chapa, Mónica...
  4. Mij

    Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk,2025,Van der Stede et al

    Highlights Mononuclear cells are primary drivers of the exercise response in skeletal muscle • Release of histamine from skeletal muscle during exercise from mast cells • Histamine receptor antagonists impair post-exercise muscle glycogen resynthesis • Exercise-induced transcriptional...
    • Mij
    • Thread
    • bdnf biopsy exercise glucose histamine il-6 insulin jak-stat mapk mast cells p53 tgf-β tnf
    • Replies: 6
    • Forum: Other health news and research
  5. SNT Gatchaman

    Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure, 2024, Saleem et al.

    Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure Mohammad Saleem; Luul A. Aden; Ashley L. Mutchler; Chitra Basu; Lale A. Ertuglu; Quanhu Sheng; Niki Penner; Anna R. Hemnes; Jennifer H. Park; Jeanne A. Ishimwe; Cheryl L. Laffer; Fernando Elijovich...
  6. SNT Gatchaman

    Exploring common pathogenic association between [EBV] and [LC] by integrating RNA-Seq and molecular dynamics simulations, 2024, Kanwal+Zhang

    Exploring common pathogenic association between Epstein Barr virus infection and long-COVID by integrating RNA-Seq and molecular dynamics simulations Kanwal, Ayesha; Zhang, Zhiyong The term "Long-COVID" (LC) is characterized by the aftereffects of COVID-19 infection. Various studies have...
  7. SNT Gatchaman

    Review Type I interferons and endoplasmic reticulum stress in health and disease, 2020, Sprooten and Garg

    Type I interferons and endoplasmic reticulum stress in health and disease Sprooten; Garg Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range...
  8. Mij

    Soluble IL-2R impairs muscle cell mitochondrial respiration in fatigued individuals with post-acute sequelae of COVID-19, 2024, Peterson Brown

    Abstract Post-acute sequelae of COVID (PASC) persist in many patients for weeks and months after recovery from initial SARS-CoV-2 infection. Recent evidence suggests that pathological changes in skeletal muscle may contribute significantly to ongoing pain and fatigue, particularly...
    • Mij
    • Thread
    • cd25 il-2 il-2r jak-stat mitochondrial dysfunction muscle biopsy oxygen use seahorse t-cells
    • Replies: 10
    • Forum: Long Covid research
  9. SNT Gatchaman

    Preprint Persistent Activation of Chronic Inflammatory Pathways in Long Covid, 2024, Aid et al.

    Persistent Activation of Chronic Inflammatory Pathways in Long Covid Malika Aid; Katherine McMahan; Nicole Hachmann; Jessica Miller; Erica Borducchi; David Hope; Marjorie Rowe; Eleanor Schonberg; Siline Thai; Ai-ris Collier; Janet Mullington; Dan Barouch Long Covid, or Post-Acute Sequelae of...
    • SNT Gatchaman
    • Thread
    • coagulation complement hla-dqb1 inflammation insulin jak-stat lipids mast cells nk cells t cells
    • Replies: 4
    • Forum: Long Covid research
  10. SNT Gatchaman

    Preprint BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III, 2024, Chen et al

    BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III Brandon Chen; Theophilus M Lynn-Nguyen; Pankaj Jadhav; Benjamin S Halligan; Nicholas J Rossiter; Rachel M Guerra; Sergei Koshkin; Imhoi Koo; Pietro Morlacchi...
    • SNT Gatchaman
    • Thread
    • brd4 complex 3 endoplasmic reticulum epigenetics hif-1 hypoxia integrated stress response jak inhibitors jak-stat mitochondria mitochondrial dynamics perk
    • Replies: 0
    • Forum: Other health news and research
  11. SNT Gatchaman

    Preprint Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19, 2024, Ashok et al.

    Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19 Deepthi Ashok; Ting Liu; Joseph Criscione; Meghana Prakash; Byunggik Kim; Julian Chow; Morgan Craney; Kyriakos Papanicolaou; Agnieszka Sidor; D. Brian Foster; Andrew Pekosz...
    • SNT Gatchaman
    • Thread
    • arrhythmia cardiac cardiac function cytokines innate immune response interferon interferon-stimulated genes jak inhibitors jak-stat macrophages mitochondria reactive oxygen species
    • Replies: 0
    • Forum: Long Covid research
  12. SNT Gatchaman

    [Preprint] Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy, 2023, Lee et al.

    Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy Jae Seung Lee; Mark Dittmar; Jesse Miller; Minghua Li; Kasirajan Ayyanathan; Max B Ferretti; Jesse Hulahan; Kanupriya Whig; Zienab Etwebi; Trevor Griesman; David C. Schultz; Sara Cherry...
  13. SNT Gatchaman

    Review The JAK/STAT signaling pathway: from bench to clinic, 2021, Hu et al.

    The JAK/STAT signaling pathway: from bench to clinic Hu, Xiaoyi; li, Jing; Fu, Maorong; Zhao, Xia; Wang, Wei The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular...
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