kallikreins

  1. Chandelier

    Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology, 2025, Griggs et al.

    https://academic.oup.com/immunohorizons/article/9/10/vlaf044/8256436?login=false Abstract Hypermobile Ehlers–Danlos Syndrome (hEDS) is a poorly understood connective tissue disorder that lacks molecular diagnostic markers. This study aimed to identify proteomic signatures associated with...
  2. Nightsong

    Preprint ME/CFS and PASC Patient-Derived Immunoglobulin Complexes Disrupt Mitochondrial Function and Alter Inflammatory Marker Secretion, 2025, Prusty et al

    Abstract: Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients' sera into mice induces some clinical features of PASC. IgG-induced...
    • Nightsong
    • Thread
    • bhupesh prusty igg immunoglobulin iron kallikreins me/cfs mitochondrial function proteomics scheibenbogen transferrin vwf
    • Replies: 24
    • Forum: ME/CFS research
  3. SNT Gatchaman

    SARS-Cov-2 Replication in a [Blood–Brain Barrier Model] Induces Permeability & Disables [ACE2] Regulation of Bradykinin B1 Receptor, 2025, Coelho+

    SARS-Cov-2 Replication in a Blood–Brain Barrier Model Established with Human Brain Microvascular Endothelial Cells Induces Permeability and Disables ACE2-Dependent Regulation of Bradykinin B1 Receptor Coelho, Sharton Vinicius Antunes; Souza, Gabriela Lisboa e; Bezerra, Bruno Braz; Lima, Luan...
  4. SNT Gatchaman

    Differential Gene Expression in the Upper Respiratory Tract following Acute COVID-19 Infection in Ambulatory Patients That Develop [LC], 2024, Biondi+

    Differential Gene Expression in the Upper Respiratory Tract following Acute COVID-19 Infection in Ambulatory Patients That Develop Long COVID Biondi, Mia J.; Addo, Mary; Zahoor, Muhammad Atif; Salvant, Elsa; Yip, Paul; Barber, Bethany; Smookler, David; Wasif, Sumaiyah; Gaete, Kayla; Kandel...
    • SNT Gatchaman
    • Thread
    • coagulation complement cpb2 epigenetics fibrinogen fibrinolysis il-7 kallikreins transcriptomics
    • Replies: 9
    • Forum: Long Covid research
  5. E

    Preprint Variants in the Kallikrein Gene Family and Hypermobile Ehlers-Danlos Syndrome, 2024, Gensemer et al

    Abstract Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks a known genetic etiology. To identify genetic contributions to hEDS, whole exome sequencing was performed on families and a cohort of sporadic hEDS patients. A missense variant in...
  6. Mij

    A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases, 2022, Devasahayam Arokiar Balaya Rex

    Abstract Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling mechanisms. Bradykinin induced signaling is mediated through kinin B1 (BDKRB1) and B2 (BDKRB2)...
  7. LarsSG

    Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC)..., 2022, Kell & Pretorius et al

    Abstract Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation of individuals with long COVID...
    • LarsSG
    • Thread
    • fibrin ighv immunoglobulin kallikreins kell long covid microclots pf4 platelets pretorius
    • Replies: 1
    • Forum: Long Covid research
  8. Andy

    Role of the Renin–Angiotensin–Aldosterone & Kinin–Kallikrein Systems in the Cardiovascular Complications of COVID-19 & Long COVID, 2021, Cooper et al

    Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to severe and life-threatening symptoms. Although COVID-19 has a respiratory focus, there are major cardiovascular...
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