kell

  1. hotblack

    Preprint Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System, 2025, Nunes +

    Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System Massimo Nunes, Loren Kell, Anouk Slaghekke, Rob Wüst, Burtram Fielding, Douglas Kell, Etheresia Pretorius Abstract Myalgic encephalomyelitis/chronic fatigue...
    • hotblack
    • Thread
    • endothelial cells endothelial dysfunction kell long covid pretorius rob wust senescence
    • Replies: 2
    • Forum: ME/CFS research
  2. Mij

    [Case Report] Treatment of Long Covid with Enoxaparin, 2025, Wright, Kell, Pretorius, Putrino

    Treatment of Long Covid with Enoxaparin, 2025, Wright, Ciara PhD, Kell, Douglas PhD, Pretorius, Resia PhD. Putrino, David PhD Abstract Background and Purpose: Long COVID is a complex multisystemic disease state, which represents a huge economic and health burden worldwide. Hypercoagulation and...
    • Mij
    • Thread
    • anticoagulation heparin kell microclots pretorius putrino treatment
    • Replies: 10
    • Forum: Long Covid research
  3. Andy

    Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclots, 2024, Kell and Pretorius

    Now published: linked here Preprint Abstract In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein monomers, with protofibrils and fibrils exhibiting a cross-beta motif of parallel or antiparallel beta-sheets oriented perpendicular to the fibre...
  4. forestglip

    [...] LC-MS/MS analysis of ME/CFS plasma reveals dysregulated coagulation [...], endothelial dysfunction, [...], 2024, Nunes, Kell, Pretorius et al

    Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius Published 16 July 2024 Abstract Myalgic...
    • forestglip
    • Thread
    • coagulation complement complement component 9 complement system endothelial function immunoglobulin kell lactotransferrin liquid chromatography tandem mass spectroscopy me/cfs platelet factor 4 platelet-poor plasma pretorius protein s s100 s100-a9 thrombospondin-1
    • Replies: 6
    • Forum: ME/CFS research
  5. RaviHVJ

    Opinion Challenging the current hypothesis that thrombosis is responsible for the post-COVID-19 condition, 2024, Carson, Davey Smith, Garner et al

    Abstract: People with the post-COVID-19 condition suffer symptoms that persist beyond 12 weeks following acute COVID-19 infection. Fatigue, shortness of breath, and cognitive dysfunction (“brain fog”) are common. Scientists, clinicians, and patients debate the pathophysiology. One...
  6. LarsSG

    Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC)..., 2022, Kell & Pretorius et al

    Abstract Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation of individuals with long COVID...
    • LarsSG
    • Thread
    • fibrin kallikreins kell long covid microclots pf4 platelets pretorius
    • Replies: 1
    • Forum: Long Covid research
  7. SNT Gatchaman

    The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS; 2022, Kell

    The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications Kell DB, Pretorius E Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species...
    • SNT Gatchaman
    • Thread
    • ischaemia-reperfusion kell long covid mast cell activation syndrome microclots oxidative stress pretorius rheumatoid arthritis
    • Replies: 5
    • Forum: Long Covid research
  8. SNT Gatchaman

    A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications, Kell, Laubscher, Pretorius, 2022

    A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications Douglas B. Kell, Gert Jacobus Laubscher and Etheresia Pretorius Post-acute sequelae of COVID (PASC), usually referred to as ‘Long COVID’ (a phenotype of COVID-19), is a relatively frequent...
  9. SNT Gatchaman

    Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation, 2016, Kell+

    Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting Douglas Kell and Etheresia Pretorius Abstract The chief and largely terminal element of normal blood clotting is...
  10. SNT Gatchaman

    Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation, 2019, Page et al

    Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation Martin J. Page, Greig J. A. thomson, J. Massimo Nunes, Anna-Mart Engelbrecht, Theo A Nell, Willem J. S. de Villiers, Maria C. de Beer, Lize Engelbrecht, Douglas B. Kell, Etheresia Pretorius Abstract Complex associations...
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