lipidomics

"We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply." Daniel Missailidis...

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry Milka Doktorova; Jessica L. Symons; Xiaoxuan Zhang; Hong-Yin Wang; Jan Schlegel; Joseph H. Lorent; Frederick A. Heberle; Erdinc Sezgin; Edward Lyman; Kandice R. Levental; Ilya Levental Membranes are molecular interfaces...

Abstract: We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...

Exertional Exhaustion Post-Exertional Malaise, PEM Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Baraniuk, James N. Post-exertional malaise (PEM) is a defining condition of myalgic...

Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach Sara Martínez; Oihane E. Albóniga; María Rosa López-Huertas; Ana Gradillas; Coral Barbas Despite the recent and increasing knowledge surrounding...

Lipidomics signature in post-COVID patient sera and its influence on the prolonged inflammatory response Abstract Background: The ongoing issues with post-COVID conditions (PCC), where symptoms persist long after the initial infection, highlight the need for research into blood lipid changes...

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants Farley, Scotland E.; Kyle, Jennifer E.; Leier, Hans C.; Bramer, Lisa M.; Weinstein, Jules B.; Bates, Timothy A.; Lee, Joon-Yong; Metz, Thomas O.; Schultz, Carsten; Tafesse, Fikadu G. A comprehensive...

Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction Lodge, Samantha; Lawler, Nathan G.; Gray, Nicola; Masuda, Reika; Nitschke, Philipp; Whiley, Luke; Bong, Sze-How; Yeap, Bu B.; Dwivedi, Girish; Spraul...

Abstract The biology driving individual patient responses to severe acute respiratory syndrome coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework leveraging detailed longitudinal phenotyping data and covering a year after disease onset, from 215...