[In mice]
Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic...
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID
Kaiming Wang; Mobin Khoramjoo; Karthik Srinivasan; Paul M.K. Gordon; Rupasri Mandal; Dana Jackson; Wendy Sligl; Maria B. Grant; Josef M. Penninger; Christoph H. Borchers; David S. Wishart...
Preprint
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease that is characterized by unexplained physical fatigue unrelieved by rest. Symptoms also include cognitive and sensory dysfunction, sleeping disturbances, orthostatic intolerance...
I am trying to get my head around the question of whether ME could be a metabolic problem, as suggested by the 'something in the blood' findings by several different researchers, and by the problems with pyruvate dehydrogenase possibly blocking or reducing complete breakdown of glucose, and by...
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