mhc

Perspective: host factors variants and the underlying causes of long COVID Tirasak Pasharawipas Long COVID, also known as post-COVID syndrome (PCS), is characterized by persistent and unexplained symptoms that can occur not only in individuals who experienced severe symptoms during the acute...

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder Strom, Nora I. and 207 others Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis...

HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases Tatsuhiko Naito, Yukinori Okada Abstract Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex region (MHC) significantly affect the risk of...

Efficient HLA imputation from sequential SNPs data by transformer Kaho Tanaka, Kosuke Kato, Naoki Nonaka & Jun Seita Abstract Human leukocyte antigen (HLA) genes are associated with a variety of diseases, yet the direct typing of HLA alleles is both time-consuming and costly. Consequently...

Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease. Saori Sakaue, Saisriram Gurajala, Michelle Curtis, Yang Luo, Wanson Choi, Kazuyoshi Ishigaki, Joyce B. Kang, Laurie Rumker, Aaron J. Deutsch, Sebastian Schönherr, Lukas Forer, Jonathon LeFaive, Christian...

The UK Biobank resource with deep phenotyping and genomic data Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T. Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrian Cortes, Samantha Welsh, Alan Young, Mark Effingham, Gil McVean...

Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response Arpita Balakrishnan, Gabriela Winiarek, Olga Ho, Jakub Godlewski, Agnieszka Bronisz Abstract The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility...

Endogenous self-peptides guard immune privilege of the central nervous system Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe...

SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition Miyu Moriyama, Carolina Lucas, Valter Silva Monteiro, Yale SARS-CoV-2 Genomic Surveillance Initiative, Akiko Iwasaki SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to...

Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci Abstract The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but...