mirna

Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight Anurag Sakharkar; Kiven Erique Lukong; Lauren M Sanders; Sylvain V Costes; Jian Yang; Changiz Taghibiglou Space exploration has captured the imagination of humanity for generations. From the first steps on the moon to...

Abstract Myalgic Encephalomyelitis / Chronic Fatigue Syndrome is a debilitating, multisystem disease of unknown mechanism, with a currently ongoing search for its endocrine mediators. Circulating microRNAs (miRNA) are a promising candidate for such a mediator and have been reported as...

Abstract MicroRNAs (miRNAs), a class of small noncoding RNAs, are critical to gene regulation in eukaryotes. They are involved in modulating a variety of physiological processes, including the host response to intracellular infections. Little is known about miRNA functions during infection by...

Cellular microRNAs target SARS-CoV-2 spike protein and restrict viral replication Kishore Vaddadi ; Chaitanya Gandikota ; Chaoqun Huang ; Yurong Liang ; Lin Liu MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and are implicated in viral replication and host tropism...

Abstract Neuropathic pain is a debilitating condition affecting around 8% of the adult population in the UK. The pathophysiology is complex and involves a wide range of processes, including alteration of neuronal excitability and synaptic transmission, dysregulated intracellular signalling and...

Ekua W. Brenu ,Kevin J. Ashton,Jana Batovska,Donald R. Staines,Sonya M. Marshall-Gradisnik Abstract Background MicroRNAs (miRNAs) are known to regulate many biological processes and their dysregulation has been associated with a variety of diseases including Chronic Fatigue Syndrome/Myalgic...

Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multifactorial disease that causes increasing morbidity worldwide, and many individuals with ME/CFS symptoms remain undiagnosed due to the lack of diagnostic biomarkers. Its etiology is still unknown, but...

Full title: Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic disease characterized by long-lasting persistent...

Abstract In recent years, the incidence of fatigue has been increasing, and the effective prevention and treatment of fatigue has become an urgent problem. As a result, the genetic research of fatigue has become a hot spot. Transcriptome-level regulation is the key link in the gene regulatory...

Open access at https://www.jci.org/articles/view/124725 Press release about the paper https://www.manchester.ac.uk/discover/news/masterswitch-discovered-in-bodys-immune-system/