Summary
We have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed...
Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10
Blanca D. Lopez-Ayllon; Silvia Marin; Marcos Farinas Fernandez; Transito Garcia-Garcia; Raul Fernandez-Rodriguez; Ana de Lucas-Rius; Natalia Redondo; Laura Mendoza-Garcia; Carles Foguet...
Mitochondria- and ER-associated actin are required for mitochondrial fusion
Priya Gatti; Cara R Schiavon; Uri Manor; Marc Germain
Mitochondria play a crucial role in the regulation of cellular metabolism and signalling. Mitochondrial activity is modulated by the processes of mitochondrial...
Fereshteh Jahanbani, Rajan D. Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J. Perrino, Damek V. Spacek, Ronald W. Davis, Michael P. Snyder
Received: January 17, 2022; Accepted: July 25, 2022; Published: August 9, 2022
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is...
electron microscopy
immune dysfunction
lipid droplets
lipid metabolism
lipids
mitochondria
mitochondrialarchitecture
omf
open medicine foundation
ron davis
smpd1
sphingolipids
t cells
Abstract
Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation1,2. A long appreciated, yet undefined relationship exists between the lytic–latent switch and viral non-coding RNAs3,4.
Here we identify viral...
Full title: The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism
Another paper examining virus-induced mitochondrial fragmentation/fission in this case by HCMV and effects of an artesunate-derived...
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