PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain
Sbei, Sami; Moncrief, Taylor; Limjunyawong, Nathachit; Zeng, Yaping; Green, Dustin P.
Migraine ranks among the most prevalent disorders worldwide, leading to disability and decreased quality of life in patients...
Abstract:
Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...
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