mrgprx2

A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response...

MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway Xinqi Mao; Jianzhang Wang; Shaojie Ding; Xinyue Guo; Xinxin Xu; Ping Xu; Xinmei Zhang The studies on how mast cells mediate endometriosis pain are still...

PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain Sbei, Sami; Moncrief, Taylor; Limjunyawong, Nathachit; Zeng, Yaping; Green, Dustin P. Migraine ranks among the most prevalent disorders worldwide, leading to disability and decreased quality of life in patients...

Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome Lisse Decraecker; María Cuende Estévez; Samuel Van Remoortel; Runze Quan; Nathalie Stakenborg; Zheng Wang; Elisabetta De Marco; Alexandre Denadai-Souza; Maria Francesca Viola; Sonia Garcia Caraballo; Stuart Brierley; Yasuhiro...

Abstract: Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...