myelin

Structural brain abnormalities and neuropsychiatric symptoms in post-COVID condition OBJECTIVES We aimed to cross-sectionally and longitudinally compare brain morphometry and neuropsychiatric symptoms, and evaluate their relationship, in participants with Post-Coronavirus Disease Condition...

Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study BACKGROUND Prolonged neurological symptoms following COVID-19 are common, yet few longitudinal studies describe brain MRI findings in this patient group. The use of...

Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study [Line breaks added] Background Diverse neurological symptoms are experienced by long COVID and COVID-19 recovered individuals. However, the long-term...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Highlights • Female long COVID (LC) patients show heightened immune activation and inflammation • Disrupted sex hormone levels differ between male and female LC patients • Neuroinflammatory gene signatures may explain...

Long term effect of COVID-19 on brain metabolism and connectivity Beatrice Bravi; Marco Paolini; Federica Colombo; Mariagrazia Palladini; Valentina Bettonagli; Mario Gennaro Mazza; Rebecca De Lorenzo; Patrizia Rovere-Querini; Francesco Benedetti; Sara Poletti AIMS After 3 years from the...

L. S. Chutko, S. Yu. Surushkina, E. A. Yakovenko & D. V. Cherednichenko We present here an overview of reports addressing studies of chronic fatigue syndrome (CFS), with consideration of results from studies of the epidemiology of this pathology in childhood and adults. The features of...

https://www.medrxiv.org/content/10.1101/2025.04.08.25325108 Abstract Post-COVID Syndrome (PCS), also known as Long COVID, is characterized by persistent and often debilitating neurological sequelae, including fatigue, cognitive dysfunction, motor deficits, and autonomic dysregulation (Dani et...

Reversible reduction in brain myelin content upon marathon running Ramos-Cabrer, Pedro; Cabrera-Zubizarreta, Alberto; Padro, Daniel; Matute-González, Mario; Rodríguez-Antigüedad, Alfredo; Matute, Carlos Here we use magnetic resonance imaging to study the impact of marathon running on brain...

Full title: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 Rebeka Fekete, Alba Simats, Eduárd Bíró, Balázs Pósfai, Csaba Cserép, Anett D. Schwarcz, Eszter Szabadits, Zsuzsanna Környei, Krisztina...

Abstract: We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...

Potential Mechanisms Underlying COVID-19-Mediated Central and Peripheral Demyelination: Roles of the RAAS and ADAM-17 Oliveira, Kellysson Bruno; de Souza, Fernanda Maria Araujo; de Sá, Letícia Barros Maurício; Pacheco, Amanda Larissa Dias; Prado, Mariana Reis; de Sousa Rodrigues, Célio Fernando...

The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders Paola Giussani; Alessandro Prinetti; Cristina Tringali Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system...

Circulating Metabolome and White Matter Hyperintensities in Women and Men Eeva Sliz; Jean Shin; Shahzad Ahmad; Dylan M. Williams; Stefan Frenzel; Friederike Gauß; Sarah E. Harris; Ann-Kristin Henning; Maria Valdes Hernandez; Yi-Han Hu; Beatriz Jiménez; Muralidharan Sargurupremraj; Carole Sudre...

MRI with generalized diffusion encoding reveals damaged white matter in patients previously hospitalized for COVID-19 and with persisting symptoms at follow-up Boito, Deneb; Eklund, Anders; Tisell, Anders; Levi, Richard; Özarslan, Evren; Blystad, Ida There is mounting evidence of the long-term...

Attenuation of ferroptosis as a potential therapeutic target for neuropsychiatric manifestations of post-COVID syndrome Sousa, Ricardo A. L.; Yehia, Asmaa; Abulseoud, Osama A. Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), is...

Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome Maria Díez-Cirarda; Miguel Yus-Fuertes; Rafael Sanchez-Sanchez; Javier J. Gonzalez-Rosa; Gabriel Gonzalez-Escamilla; Lidia Gil-Martínez; Cristina Delgado-Alonso...

What lies beneath: White matter microstructure in pediatric myalgic encephalomyelitis/chronic fatigue syndrome using diffusion MRI Elisha K. Josev; Jian Chen; Marc Seal; Adam Scheinberg; Rebecca C. Cole; Katherine Rowe; Lionel Lubitz; Sarah J. Knight Recent studies in adults with myalgic...

Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19 Huajun Liang; Thomas Ernst; Kenichi Oishi; Meghann C. Ryan; Edward Herskovits; Eric Cunningham; Eleanor Wilson; Shyamasundaran Kottilil; Linda Chang Objectives We aimed to compare brain white...

Now published - link here Preprint Rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled magnetic resonance imaging data using deep neural network Zhaoyuan Gong, Nikkita Khattar, Matthew Kiely, Curtis Triebswetter, Mustapha Bouhrara Changes in myelination...

Myelin lipid metabolism and its role in myelination and myelin maintenance Barnes-Vélez JA, Aksoy Yasar FB, Hu J Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its...