narcolepsy

Global estimates of vaccine-associated narcolepsy from 1967 to 2023 Regional evidence on the signal detection between narcolepsy and vaccines is scarcely available and insufficiently understood, thus impeding a comprehensive understanding of this relationship on a global scale. Therefore, this...

Age at onset of narcolepsy in two large populations of patients in France and Quebec Authors: Y Dauvilliers, J Montplaisir, N Molinari, B Carlander, B Ondze, A Besset, M Billiard Abstract Background Narcolepsy usually starts around adolescence; however, there is great variability in the...

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy Abstract Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of...

HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data...

Significance This study establishes how narcolepsy type 1 (NT1) affects brain fluid dynamics through lack of orexins by comparing NT1 patients to healthy wake and sleeping controls. Using fast functional MRI, we revealed that even during wakefulness, NT1 leads to high vasomotor and low brain...

https://www.pharmacytimes.com/news/fda-approves-pitolisant-for-daytime-sleepiness-in-patients-with-narcolepsy Wonder if this could help with fatigue in mecfs?

https://neurosciencenews.com/narcolepsy-autoimmune-disease-10902/