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nf-κb
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Preprint MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by Preserving Mitochondrial Integrity, 2025, Sah et al.
MAVS Orchestrates a Potent IFN-independent Antiviral Immunity by Preserving Mitochondrial Integrity Vishal Sah; Poojitha Sai Potharaju; Karthika S Nair; Prangya Paramita Sahoo; Abhiram Ravicanti Pooja; Debasmita Basu; Dixit Tandel; K S Varadarajan; Santosh Chauhan; Anant Bahadur Patel; Krishnan...- SNT Gatchaman
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- autophagy inteferon mavs mitophagy nf-κb pink1
- Replies: 1
- Forum: Other health news and research
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CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling, 2025, Wen+
CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling Wen, Yi-hong; Zhao, Heng-li; Wu, Shao-yu; Jiang, Jia-xue; Gao, Yuan; Wang, Zi-fan; Liu, Xiao-yao; Yu, Fei; Ou, Tao; Zhao, An-zhi; Chen, Li-wen; Fang...- SNT Gatchaman
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- atf7 endothelial cells endothelial dysfunction micro-rna nf-κb reactive oxygen species tlr-4 toll-like receptor
- Replies: 0
- Forum: Long Covid research
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Review Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Syed, Karius, Wang, Hwang
Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...- SNT Gatchaman
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- actin atp eif2a endoplasmic reticulum er stress interferon jak-stat mitochochria mitochondrial dysfunction nf-κb wasf3
- Replies: 15
- Forum: ME/CFS research
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Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Monocytes, Avoiding [LC], 2025, Olivares-Martínez+
Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID Olivares-Martínez, Elizabeth; Hernández-Ramírez, Diego Francisco; Núñez-Álvarez, Carlos Alberto; Meza-Sánchez, David Eduardo; Chapa, Mónica...- SNT Gatchaman
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- collagen ecm interferon jak-stat lair1 macrophages monocytes nf-κb p38 stat1
- Replies: 3
- Forum: Long Covid research
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[NF-κB], interferon regulatory Factor, and glucocorticoid receptor pathway activation in [depression]: The role of [CMV], 2024, Savitz+
Nuclear factor kappa-B cell NF-κB, interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection Savitz; McKinney; Meier; Zheng; Ford; Yolken; Teague; Cole Altered activity of major immunoregulatory pathways has...- SNT Gatchaman
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- cmv depression glucocorticoid receptor interferon monocytes nf-κb t cells
- Replies: 0
- Forum: Other health news and research
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CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID, 2024, Dilip Thomas et al
Abstract Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown. Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...- Mij
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- acetylcholine calcium cardiac ccl2 cytokines endothelial cells endotheliitis fibronectin glycocalyx il-6 monocytes nf-κb nitric oxide spike protein
- Replies: 4
- Forum: Long Covid research
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Sex differences and immune correlates of Long COVID development, persistence, and resolution, 2024, Hamlin et al.
Sex differences and immune correlates of Long COVID development, persistence, and resolution Rebecca E Hamlin; Shaun M Pienkos; Leslie Chan; Mikayla A Stabile; Kassandra Pinedo; Mallika Rao; Philip Grant; Hector Bonilla; Marisa Holubar; Upinder Singh; Karen B Jacobson; Prasanna Jagannathan...- SNT Gatchaman
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- ets1 integrins interferon interferon-y monocytes nf-κb nk cells sex differences t cells tgf-beta
- Replies: 7
- Forum: Long Covid research
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TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells, 2024, Landolina et al.
TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells Landolina, Nadine; Ricci, Biancamaria; Veneziani, Irene; Alicata, Claudia; Mariotti, Francesca Romana; Pelosi, Andrea; Quatrini, Linda; Mortari, Eva Piano; Carsetti, Rita; Vacca, Paola; Tumino, Nicola; Azzarone...- SNT Gatchaman
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- covid interferon nf-κb nk cells spike protein tlr-2 tlr-4
- Replies: 1
- Forum: Long Covid research
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Review Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury, 2024, Czyżewski et al.
Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury Czyżewski, Wojciech; Litak, Jakub; Sobstyl, Jan; Mandat, Tomasz; Torres, Kamil; Staśkiewicz, Grzegorz Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the...- SNT Gatchaman
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- aquaporin csf mapk mmp-9 nf-κb sirt tlr-4 tlr-9 traumatic brain injury vasopressin vegf
- Replies: 0
- Forum: Other health news and research
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Preprint Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with coronary artery disease, 2024, Mjörnstedt+
Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery disease. Filip Mjörnstedt; Rebecka Wilhelmsson; Marcus Ulleryd; Maria Hammarlund; Göran Bergström; Anders Gummesson; Maria E Johansson BACKGROUND The...- SNT Gatchaman
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- a7nachr acetylcholine coronary arteries il-6 nf-κb pbmc statins
- Replies: 1
- Forum: Other health news and research
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Divergent mechanisms regulate TLR4 expression on PBMCs following workload-matched exercise in normoxic and hypoxic environments, 2023, et al.
Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments Jeremy B. Ducharme ; Zachary J. McKenna ; Jonathan W. Specht ; Zachary J. Fennel ; Quint N. Berkemeier ; Michael R. Deyhle Exercise...- SNT Gatchaman
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- exercise gut permeability hif-1 hypoxia nf-κb pbmc tlr-4 toll-like receptor
- Replies: 2
- Forum: Other health news and research
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Helicobacter pylori induces a novel form of innate immune memory via accumulation of NF-кB proteins, 2023, Frauenlob et al.
Helicobacter pylori induces a novel form of innate immune memory via accumulation of NF-кB proteins Frauenlob, Tobias; Neuper, Theresa; Regl, Christof; Schaepertoens, Veronika; Unger, Michael S.; Oswald, Anna-Lena; Dang, Hieu-Hoa; Huber, Christian G.; Aberger, Fritz; Wessler, Silja...- SNT Gatchaman
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- helicobacter pylori innate immune response innate immune system monocytes nf-κb
- Replies: 3
- Forum: Other health news and research
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Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS Spike Protein in Human Cell Culture, 2023, Aguida +
Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS-CoV-2 Spike Protein in Human Cell Culture Aguida, Blanche; Chabi, Marie-Marthe; Baouz, Soria; Mould, Rhys; Bell, Jimmy D.; Pooam, Marootpong; André, Sebastien; Archambault, Dominique; Ahmad...- SNT Gatchaman
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- cytochrome c oxidase il-6 mitochondria near infrared nf-κb reactive oxygen species ros sars-cov-2 spike protein tlr-4
- Replies: 1
- Forum: Epidemics (including Covid-19, not Long Covid)
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Preliminary Evidence of the Differential Expression of HERVs in Kawasaki Disease and SARS-CoV-2-Associated MIS-C, 2023, Balestrieri et al.
Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children Balestrieri, Emanuela; Corinaldesi, Elena; Fabi, Marianna; Cipriani, Chiara; Giudice, Martina; Conti, Allegra...- SNT Gatchaman
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- children herv herv-k herv-w il-6 kawasaki mis-c nf-κb retrovirus sars-cov-2 spike protein syncitin tlr-4
- Replies: 0
- Forum: Long Covid research
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COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway, 2023, Mroueh et al.
COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway Ali Mroueh; Walaa Fakih; Adrien Carmona; Antonin Trimaille; Kensuke Matsushita; Benjamin Marchandot; Abdul Wahid Qureshi; Dal-Seong Gong; Cyril Auger; Laurent Sattler...- SNT Gatchaman
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- coagulation covid-19 cytokines endothelial dysfunction enos il-1b il-6 nf-κb nitric oxide oxidative stress platelets redox tnf
- Replies: 0
- Forum: Long Covid research
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SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile, 2023, Zhang et al.
SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile Zhang, Jia-Yuan; Whalley, Justin P.; Knight, Julian C.; Wicker, Linda S.; Todd, John A.; Ferreira, Ricardo C. The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in...- SNT Gatchaman
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- autoimmunity b-cells ecm extracellular matrix il-2 inflammation long covid monocytes nf-κb nk cells sars-cov-2 t-cells tnf
- Replies: 1
- Forum: Long Covid research
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Review The JAK/STAT signaling pathway: from bench to clinic, 2021, Hu et al.
The JAK/STAT signaling pathway: from bench to clinic Hu, Xiaoyi; li, Jing; Fu, Maorong; Zhao, Xia; Wang, Wei The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular...- SNT Gatchaman
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- jak inhibitors jak-stat nf-κb stat tgf-beta
- Replies: 1
- Forum: Other health news and research
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SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication, 2023, Montezano et al.
SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication Montezano, Augusto C.; Camargo, Livia L.; Mary, Sheon; Neves, Karla B; Rios, Francisco J; Stein, Ross; Lopes, Rheure A.; Beattie, Wendy; Thomson, Jacqueline; Herder, Vanessa; Szemiel, Agnieszka...- SNT Gatchaman
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- ace2 atf4 bip endoplasmic reticulum eran segal grp78 nf-κb sars-cov-2 spike protein
- Replies: 5
- Forum: Long Covid research
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Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function, 2023, Iosef et al
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function Iosef, Cristiana; Knauer, Michael J.; Nicholson, Michael; Van Nynatten, Logan R.; Cepinskas, Gediminas; Draghici, Sorin; Han, Victor K. M.; Fraser, Douglas D. Aims...- SNT Gatchaman
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- ang-1 hif-1 long covid neutrophil extracellular traps neutrophils nf-κb nk cells tnf vascular vegf
- Replies: 3
- Forum: Long Covid research
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Persistent serum protein signatures define an inflammatory subcategory of long COVID, 2023, Talla et al.
Persistent serum protein signatures define an inflammatory subcategory of long COVID Talla, Aarthi; Vasaikar, Suhas V.; Szeto, Gregory Lee; Lemos, Maria P.; Czartoski, Julie L.; MacMillan, Hugh; Moodie, Zoe; Cohen, Kristen W.; Fleming, Lamar B.; Thomson, Zachary; Okada, Lauren; Becker, Lynne A...- SNT Gatchaman
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- annexin ifna ifny inflammation interferon long covid neutrophil extracellular traps neutrophils nf-κb proteomics serum
- Replies: 7
- Forum: Long Covid research