Attenuated cardiac autonomic function in patients with long-COVID with impaired orthostatic hemodynamics
Hira, Rashmin; Baker, Jacquie R.; Siddiqui, Tanya; Patel, Aishani; Valani, Felix Gabriel Ayala; Lloyd, Matthew G.; Floras, John S.; Morillo, Carlos A.; Sheldon, Robert S.; Raj, Satish R...
Signicant Microvascular Abnormalities Are Present in Autonomic Dysfunction: Results of a Prospective Study
Sehreen Mumtaz, et. al.
Abstract
Purpose The prevalence and phenotype of capillaroscopic abnormalities in patients with autonomic nervous system dysfunction has not been investigated...
Orthostatic Intolerance in Children With Long COVID Utilizing a 10-Minute Passive Standing Test
Amanda K. Morrow; Cindy Villatoro; Christina Kokorelis; Peter C. Rowe; Laura A. Malone
Despite there being a wide variety of symptoms reported in pediatric long COVID, one condition that has become...
written by: Mitchell G. Miglis, Noor Syed, Melissa M. Cortez, Frans C. Viser, C. Linda MC van Campen, Peter Novak
Unfortunately one can only see the references here:
https://link.springer.com/article/10.1007/s10286-024-01036-1
One can see the start of the letter here...
I'd love to see a discussion about the different kinds of abnormalities of heart rate and blood pressure during tilt testing that Frans Visser talked about on the NIH ME/CFS Research Roadmap: Circulation Webinar (January 11, 2024):
- POTS
- Orthostatic hypotension
- Syncope
- No POTS, normal...
Autoimmunity in Syndromes of Orthostatic Intolerance: An Updated Review
Pena, Clarissa; Moustafa, Abdelmoniem; Mohamed, Abdel-Rhman; Grubb, Blair
Orthostatic intolerance is a broad term that represents a spectrum of dysautonomic disorders, including postural orthostatic tachycardia syndrome...
Preprint now published. See post #6
https://www.medrxiv.org/content/10.1101/2023.12.18.23299958v1
Prevalence of orthostatic intolerance in Long Covid clinic patients – A multicentre observational study
Cassie Lee1(0009-0004-9449-0932) Darren C Greenwood2, Harsha Master3, Kumaran...
Autonomic Manifestations of Long-COVID Syndrome
Hira, Rashmin; Karalasingham, Kavithra; Baker, Jacquie R.; Raj, Satish R.
Purpose of Review
Long-COVID is a novel condition emerging from the COVID-19 pandemic. Long-COVID is characterized by symptoms commonly seen in autonomic disorders including...
Abstract
Purpose
Orthostatic hypotension is a common condition with heterogeneous and, in many cases, unclear underlying pathophysiology. Frequent symptoms are syncope and falls with a strong impact on daily life. A two-generation family with eight individuals segregating early-onset severe...
Absolutes are almost never true in clinical medicine, and it is likely that anecdotal cases of orthostatic hypotension (OH) in patients without autonomic failure will be reported in response to this article. Nevertheless, the purpose of this commentary, and its provocative title is to make the...
Detecting Orthostatic Intolerance in Long COVID in a Clinic Setting
Isaac, Robert Oliver; Corrado, Joanna; Sivan, Manoj
Introduction:
A likely mechanism of Long COVID (LC) is dysautonomia, manifesting as orthostatic intolerance (OI). In our LC service, all patients underwent a National...
Summary
Orthostatic hypotension is an unusually large decrease in blood pressure on standing that increases the risk of adverse outcomes even when asymptomatic. Improvements in haemodynamic profiling with continuous blood pressure measurements have uncovered four major subtypes: initial...
Abstract
In normal subjects natriuresis is tightly coupled to dietary salt ingestion to maintain sodium balance. Likewise, blood pressure remains unchanged over a wide range of salt intake because of pressure natriuresis, whereby an increase in blood pressure stimulates renal sodium excretion...
Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Abstract
Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul...
Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience
Abstract
Background
Hematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for...
Phase 2 trial:
Abstract
Purpose
In neurogenic orthostatic hypotension, blood pressure falls when upright owing to impaired release of norepinephrine, leading to dizziness. Ampreloxetine, a selective norepinephrine reuptake inhibitor, increases circulating norepinephrine levels. This study...
Abstract
The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other...
Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome
Abstract:
Rationale: Orthostatic hypotension is a common clinical problem, but the underlying mechanisms have not been fully delineated.
Objective: We describe two families, with four patients in total, suffering from...
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