pathogenesis

After a long time and a lot of work, our hypothesis on the development of ME/CFS following an Epstein Barr virus infection has finally been published...

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with unknown etiology, no validated specific and sensitive biomarker, and no standard approved effective treatment. ME/CFS has a profound impact on the quality of life of both patients and caregivers and entails high costs...

Trends in Molecular Medicine Insights from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome May Help Unravel the Pathogenesis of Post-Acute COVID-19 Syndrome Anthony L. Komaroff, W. Ian Lipkin Highlights • In some people, the aftermath of acute COVID-19 is a lingering illness with fatigue...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) involves severe fatigue, unrefreshing sleep, and cognitive impairment, leading to functional difficulties; prior studies have not evaluated risk factors with behavioral and immune data collected prior to developing...

Paywall, https://www.nature.com/articles/s41584-020-00506-w Sci hub, https://sci-hub.se/10.1038/s41584-020-00506-w

Not a recommendation http://thebiomedicapk.com/articles/819.pdf ORIGINAL ARTICLE Mental Health and Chronic Fatigue Syndrome: Is Mental Health the Culprit Behind Your Fatigue?

https://threadreaderapp.com/thread/1272740501968449536.html

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30136-X/fulltext

https://www.frontiersin.org/articles/10.3389/fimmu.2020.00578/full Excerpt: In conclusion, our study shows that the PTPN22 rs2476601 and CTLA4 rs3087243 autoimmunity risk variants are more frequent in patients with ITO ME/CFS. This finding provides further evidence that there is a genetic...

Free full text: https://www.sciencedirect.com/science/article/pii/S0306987720301559

One of the complications of making first contact with EBV at an older age appears to be ME/CFS. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393566/

“We need to know what causes one of the most debilitating health conditions, which is ME/CFS. The best way to figure this out is to identify healthy individuals and then observe what occurs when they are infected with something that might be triggering the disease, such as a virus, like...

Full title: A Framework for Understanding the Role of Psychological Processes in Disease Development, Maintenance, and Treatment: The 3P-Disease Model Open access, https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02498/full

Link I thought I'd post this preliminary finding here so it gets some exposure. Credit to @wigglethemouse for digging in and finding this study. I believe it's part of Columbia's ME/CFS CFE and hopefully will be published soon.

https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1468-2

https://www.mdpi.com/2075-4418/9/3/82

Copied from the New Zealand thread This is the paper she is referring to: The pathway from glandular fever to chronic fatigue syndrome: can the cognitive behavioural model provide the map? I think the paper is worth a discussion because it is one of the few papers that actually tried to test...

Preview (abstract only) at https://www.researchgate.net/publication/330901648_The_'Cognitive_Behavioural_Model'_of_Chronic_Fatigue_Syndrome_Critique_of_a_Flawed_Model

Paywalled at https://www.medical-hypotheses.com/article/S0306-9877(18)30548-6/fulltext

Merged thread Why Attributing 'Type A' Personalities to Myalgic Encephalomyelitis Needs to Stop "I recently had an experience with a relative that caught me off guard. In passing, she mentioned reading somewhere that it’s mostly “type A” individuals who develop ME (myalgic encephalomyelitis)...