Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA PAX LC: a double-blind, randomised, placebo-controlled, phase 2, decentralised trial
Mitsuaki Sawano; Bornali Bhattacharjee; César Caraballo; Rohan Khera; Shu-Xia Li; Jeph Herrin; Dany Christian; Andreas...
Risk of Post-Acute Sequelae of COVID-19 and Oral Antivirals in Adults Aged Over 60 years: A Nationwide Retrospective Cohort Study
Hyejin Jooa, Eunji Kimc, Kyungmin Huhd, Gi Hwan Baea, Hyungmin Leee, Jungyeon Kime, Dong-Hwi Kime, Min-Gyu Yooe, Il Uk Joi, Poong Hoon Leei, Geun Woo Leei, Hee Sun...
Hospitalizations and Mortality Among Older Adults With and Without Restricted Access to Nirmatrelvir-Ritonavir
John N. Mafi, Sitaram Vangala, Moira K. Kapral, Peter E. Wu, Manying Cui, Artem Romanov, Katherine L. Kahn
Abstract
Randomized clinical trials of nirmatrelvir-ritonavir found reduced...
Anticoagulant vs. antiviral therapy, recovery and neurodamage in Long COVID: a real-world prospective cohort study
Marc Jamoulle, Margaux Mignolet, Isabelle Meyts, Aurelie Ladang, Charles Nicaise, Johan Van Weyenbergh
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Abstract
Recent estimates consider that Long COVID...
Real-World Effectiveness of Nirmatrelvir in Protecting Long COVID for Outpatient Adult Patients – A Large-Scale Observational Cohort Study from the RECOVER Initiative
Fei Wang; Chengxi Zang; Haoyang Li; Dhru Khullar; Yongkang Zhang; Stephenson Strobel; Yong Chen; Marc Sala; Payal Patel...
Effect of Paxlovid Treatment on Long COVID Onset: An EHR-Based Target Trial Emulation from N3C
Alexander Preiss; Abhishek Bhatia; Chengxi Zang; Leyna V Aragon; John M Baratta; Monika Baskaran; Frank Blancero; M Daniel Brannock; Robert F Chew; Ivan Diaz; Megan Fitzgerald; Elizabeth P Kelly...
The study reveals a higher-than-previously-reported number of patients experienced a rebound after Paxlovid treatment, challenging previous assumptions.
Despite receiving Paxlovid, individuals with long COVID exhibited similar symptoms to those who didn’t receive the treatment.
However, the...
Nirmatrelvir/ritonavir and risk of long COVID symptoms: A retrospective cohort study
We conducted a retrospective cohort study to assess whether treatment with nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 adults with confirmed SARS-CoV-2 who were...
Medpage Today Stanford Study of Paxlovid for Long COVID Stopped Early
Quote:
Two sources familiar with the STOP-PASC study told MedPage Today that trial enrollment had been halted. One was told by a study coordinator that a preliminary review found "inconclusive evidence" for the primary...
imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC)
https://clinicaltrials.gov/ct2/show/NCT05823896
Petter Brodin
Karolinska Institutet, Sweden
"Brief Summary:
The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with...
Key Points
Question Is treatment with nirmatrelvir in the acute phase of SARS-CoV-2 infection associated with a lower risk of post–COVID-19 condition (PCC)?
Findings In this cohort study of 281 793 people with SARS-CoV-2 infection who had at least 1 risk factor for progression to severe...
Abstract:
Long Covid -- the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC) -- affects millions of people around the world. Prevention of PASC is an urgent public health priority. In this work, we aimed to examine whether treatment with nirmatrelvir in the acute phase of...
The RECOVER Initiative is doing a trial on Paxlovid for long Covid. Here's the listing on ClinicalTrials.gov:
SARS CoV-2 Viral Persistence Study (PASC) - Study of Long COVID-19 (PASC)
Highlights:
Double-blind multi-center trial in the US
1700 participants
They'll take the drug for 15 days...
Split from
Mail Online: Why many of those struck by Long Covid may be suffering from glandular fever: Blood tests on some patients are coming back positive for ‘
Here is a link from ME-pedia on the use use of valaciclovir.
The study that is mentioned on this page showed that, " Improvement...
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