pbmc

  1. Nightsong

    Preprint Comparing DNA Methylation Landscapes in Peripheral Blood from [ME/CFS] and Long COVID Patients, 2025, Peppercorn et al

    Abstract Post-viral conditions, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC), share >95% of their symptoms, but the connection between disturbances in their underlying molecular biology is unclear. This study investigates DNA methylation patterns in peripheral...
  2. Nightsong

    Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID, 2025, Hansen et al

    Abstract: Long COVID represents a significant global health challenge with an unclear etiology. Alongside accumulating evidence of mitochondrial dysfunction in patients with acute SARS-CoV-2 infection, a symptomatic overlap exists between long COVID and mitochondrial disorders. However, the...
    • Nightsong
    • Thread
    • bioenergetics genetic long covid mitochondrial dysfunction pbmc proteomics wes wgs whole genome sequencing
    • Replies: 2
    • Forum: Long Covid research
  3. Nightsong

    Preprint Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination, 2025, Bhattacharjee et al

    Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...
    • Nightsong
    • Thread
    • aquaporin autoantibodies b cells calprotectin covid ebv fetuin flow cytometry iwasaki monocytes pbmc sars-cov-2 spike protein vaccination
    • Replies: 11
    • Forum: Other health news and research
  4. Nightsong

    Gulf War Illness Induced Sex-Specific Transcriptional Differences Under Stressful Conditions, 2025, Frank et al

    Abstract Gulf War Illness (GWI) is a multi-symptom disorder affecting 1990–1991 Persian Gulf War veterans and is characterized by post-exertional malaise, neurological symptoms, immune deregulation, and exhaustion. Causation is not understood, and effective diagnostics and therapies have not yet...
  5. Wyva

    Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing, 2024, Sun et al

    Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...
    • Wyva
    • Thread
    • 2024 amyloid amyloid precursor protein biomarker cd74 china cytoskeleton esrra hla hla-dqb1 immune dysregulation immunometabolism integrated stress response nk cells oestrogen pbmc resistin single-cell rna-sequencing t cells
    • Replies: 26
    • Forum: ME/CFS research
  6. SNT Gatchaman

    Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID, 2024, Fracella et al.

    Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID Matteo Fracella; Enrica Mancino; Raffaella Nenna; Chiara Virgillito; Federica Frasca; Alessandra D'Auria; Leonardo Sorrentino; Laura Petrarca; Domenico La Regina; Luigi Matera; Greta Di...
  7. SNT Gatchaman

    Preprint Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with coronary artery disease, 2024, Mjörnstedt+

    Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery disease. Filip Mjörnstedt; Rebecka Wilhelmsson; Marcus Ulleryd; Maria Hammarlund; Göran Bergström; Anders Gummesson; Maria E Johansson BACKGROUND The...
  8. Mij

    Single-cell RNA-Seq reveals intracellular microbial diversity within immune cells during SARS-CoV-2 infection and recovery, 2023, Sunita Yadav et al

    Highlights 76 bacterial species of 15 genera across healthy, COVID-19-positive, and recovered individuals Higher abundance of opportunistic intracellular bacteria in recovered group Higher microbial abundance within antigen-presenting cells of COVID-19 patients Differential microbial abundance...
    • Mij
    • Thread
    • b cells covid dendritic cells innate immune response intracellular infection intracellular pathogen macrophages monocytes nk cells pbmc plasma cells platelets single-cell transcriptomics t cells
    • Replies: 6
    • Forum: Epidemics (including Covid-19, not Long Covid)
  9. SNT Gatchaman

    Patients with [CFS] performed worse than controls in a controlled repeated exercise study despite normal oxidative phosphorylation, 2010, Vermeulen +

    Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity Vermeulen, Ruud CW; Kurk, Ruud M; Visser, Frans C; Sluiter, Wim; Scholte, Hans R Background The aim of this study was to investigate...
    • SNT Gatchaman
    • Thread
    • cpet creatine kinase lactate mitochondria muscle oxidative phosphorylation pbmc
    • Replies: 7
    • Forum: ME/CFS research
  10. SNT Gatchaman

    Divergent mechanisms regulate TLR4 expression on PBMCs following workload-matched exercise in normoxic and hypoxic environments, 2023, et al.

    Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments Jeremy B. Ducharme ; Zachary J. McKenna ; Jonathan W. Specht ; Zachary J. Fennel ; Quint N. Berkemeier ; Michael R. Deyhle Exercise...
  11. SNT Gatchaman

    Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics, 2023, Leite et al.

    Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time Giuseppe Gianini Figueirêdo Leite; Milena Karina Colo Brunialti; Paula M. Peçanha-Pietrobom; Paulo R. Abrão Ferreira; Jaquelina Sonoe Ota-Arakaki; Edecio...
    • SNT Gatchaman
    • Thread
    • covid 19 fatty acid metabolism glycolysis mitochondria neutrophil extracellular traps neutrophils oxphos pbmc pentose phospate pathway proteomics sars-cov-2
    • Replies: 1
    • Forum: Long Covid research
  12. SNT Gatchaman

    Preprint A 50-gene high-risk profile predictive of COVID & pulmonary fibrosis mortality from molecular imbalance in monocyte & T-cell subsets, 2023, Tourki +

    A 50-gene high-risk profile predictive of COVID-19 and Idiopathic Pulmonary Fibrosis mortality originates from a molecular imbalance in monocyte and T-cell subsets that reverses in survivors with post-COVID-19 Interstitial Lung Disease Bochra Tourki; Minxue Jia; Theodoros Karampitsakos; Iset M...
    • SNT Gatchaman
    • Thread
    • cd163 fibrosis gene expression hspc il-6 ild ipf lung fibrosis lungs monocytes pbmc sars-cov-2 tgf-beta
    • Replies: 2
    • Forum: Long Covid research
  13. SNT Gatchaman

    Diminished vasculogenesis under inflammatory conditions is mediated by Activin A, 2023, Manohar-Sindhu et al.

    Diminished vasculogenesis under inflammatory conditions is mediated by Activin A Manohar-Sindhu, Sahana; Merfeld-Clauss, Stephanie; Goddard, Yana; March, Keith L.; Traktuev, Dmitry O. Severe inflammatory stress often leads to vessel rarefaction and fibrosis, resulting in limited tissue...
  14. SNT Gatchaman

    Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire, 2023, Gordon-Lipkin et al.

    Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire Gordon-Lipkin, Eliza M.; Banerjee, Payal; Franco, Jose Luis Marin; Tarasenko, Tatiana; Kruk, Shannon; Thompson, Elizabeth; Gildea, Derek E.; Zhang, Suiyuan; Wolfsberg, Tyra G.; NISC Comparative...
  15. SNT Gatchaman

    Preprint Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures, 2023, Wang et al.

    Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures Wenliang Wang; Manoj Hariharan; Anna Bartlett; Cesar Barragan; Rosa Castanon; Vince Rothenberg; Haili Song; Joseph Nery; Andrew Aldridge; Jordan Altshul; Mia Kenworthy; Wubin Ding; Hanqing Liu; Wei...
    • SNT Gatchaman
    • Thread
    • chemical exposure dna dna methylation epigenetics epigenomics immune cells immune system infection methylation pbmc single-cell genomics
    • Replies: 6
    • Forum: Other health news and research
  16. Sly Saint

    Stress-Induced Transcriptomic Changes in Females with ME/CFS Reveal Disrupted Immune Signatures, 2023, van Booven et al.

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional malaise (PEM), which is defined as a worsening of symptoms following even minor physical or mental exertion. Our...
    • Sly Saint
    • Thread
    • exercise test gene expression immune dysfunction me/cfs pbmc
    • Replies: 26
    • Forum: ME/CFS research
  17. Kalliope

    Journal of Leukocyte Biology - Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post-COVID-19 sequelae, Díaz-Resendiz et al, 2022

    Abstract The mitochondrial membrane potential (ΔΨm) is a parameter often used to determine mitochondrial function; therefore, it can be used to determine the integrity and functionality of cells. A decrement of ΔΨm is implicated in several inflammatory-related pathologies, such phenomena can be...
  18. J

    A Molecular network approach reveals shared cellular and molecular signatures between CFS and other fatiguing illnesses, 2021, Comella et al

    Full title: A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses https://www.medrxiv.org/content/10.1101/2021.01.29.21250755v1
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