post exertional malaise

Do you get delayed PEM that makes your ME/CFS more severe for a day or more, up to and including permanently? I have started this thread to focus entirely on each poster describing your own experience of PEM. My aim is that we avoid theorising about the underlying biology - keep the focus on...

https://www.lidsen.com/journals/neurobiology/neurobiology-09-01-267 Abstract Following mental or physical exertion, patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience Post-Exertional Malaise (PEM). Although self-report questions represent less expensive and...

Virtual rehabilitation for individuals with Long COVID: a randomized controlled trial Tania Janaudis-Ferreira; Marla K. Beauchamp; Amanda Rizk; Catherine M. Tansey; Maria Sedeno; Laura Barreto; Jean Bourbeau; Bryan A. Ross; Andrea Benedetti; Pei Zhi Li; Kriti Agarwal; Rebecca Zucco; Julie Lopez...

PEM could be described as an overload problem. If too much of something yet to be identified happens, then we crash and recover slowly. But what is being overloaded? Is it the energy production systems due to excessive demand? Is it the waste clearing systems? Is it the repair and maintenance...

Abstract Essential elements of Myalgic Encephalomyelitis (ME) are muscle (weakness) and tenderness, cognitive deficits, neurological impairments, especially of cognitive, autonomic and sensory functions, but above all, post-exertional “malaise”: a prolonged increase of symptoms after a minor...

High proportions of post-exertional malaise and orthostatic intolerance in people living with post-COVID-19 condition: the PRIME post-COVID study Demi ME Pagen; Maarten Van Herck; Celine JA van Bilsen; Stephanie Brinkhues; Kevin Konings; Casper DJ den Heijer; Martijn A Spruit; Christian JPA...

3 Years Into Long COVID: Where Do We Go From Here? https://www.medscape.com/viewarticle/993827 "... approximately 6% of all US adults are currently experiencing long COVID, with Hispanic/Latinx individuals, transgender individuals, and cis female individuals facing the highest rates."...

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection IMPORTANCE SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as...

New thread created by collecting posts from a number of other threads If someone's in a listening mood, there's no transcript. 30 minutes with the NIH Recover initiative lead: Direct link: https://www.nejm.org/action/showMediaPlayer?doi=10.1056/NEJMdo006435&aid=10.1056/NEJMe2201619&area=.

This description in a paper on sarcoidosis sounds like PEM (although not much detail is given so it's not clear). In this study they also performed repeated CPET and found "no impairment of maximal exercise testing" on the second test...

Pain is not one of my usual ME/CFS symptoms. When I overexert myself physically and subsequently have post-exertional malaise, my muscles (especially those which I used the most) feel leaden, sore, but not stiff, and they burn. I can relate to the often used description of feeling “poisoned”...

Hi All, It's be really interested in what people's thoughts are for the most accurate fatigue scales that can be used in research studies? Ones that also give representation to PEM over time. The CFQ (chalder fatigue scale/ questionnaire) is often used but has serious limitations. The DePaul...

I read an account by a housebound ME patient about being able to handle very short car trips as a passenger, while longer ones flare their symptoms even though they remain as idle as possible. Such a flare could only plausibly be induced by sensory stimuli during the trip, among which vehicle...

Not yet recruiting https://www.medifind.com/conditions/chronic-fatigue-syndrome/1135/clinical-trial/223304133

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02683-4

https://www.tandfonline.com/doi/abs/10.1080/21641846.2020.1845287

So one challenge that I believe we face is that if most, if not all, research studies insist on PEM as part of the inclusion criteria, we run the risk of mild sufferers not recognising PEM for what it is. For example, CCC description of PEM and ICC description of PENE I would not have...