prostaglandins

Hi all, I saw some discussion of NSAIDs already here: https://www.s4me.info/threads/nsaids.6504/ I wanted to make another thread specifically to talk about the timing of when NSAIDs are taken, and if that has an effect on helping with symptoms. Added: I'm only discussing NSAIDs for my...

Full title: Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID Abstract Background Patients with Long COVID (LC) often experience neuropsychiatric symptoms such as...

PGE2 and HCN2 ion channels are critical mediators of pain initiated by angiotensin II Pinto; Vilar; McNaughton Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), and more recent studies have shown that...

Purpose: The exact etiology of Postural Orthostatic Tachycardia Syndrome (POTS) is still unknown but is likely heterogeneous and multifaceted, involving autoimmune, neuropathic, hypovolemic, and hyperadrenergic pathways. Recently, more research has been devoted to understanding POTS’s underlying...

Full title: Mild to moderate post-Covid-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity-level- and observational sub-analysis fit- Covid study, 2023, Bruna Spolador de Alencar Silva et al Aim: This study...

Abstract Background COVID-19 is associated with a dysregulated immune response but it is unclear how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 patients during convalescence (long COVID). Methods We assessed phenotypical and functional changes of...

Abstract Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediators, many of which are detected by neurons3,4; yet, the responding neural...

Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes Edward Richardson, David García-Bernal, Eleonora Calabretta, Rubén Jara, Marta Palomo, Rebecca M Baron, Gregory Yanik, Jawed Fareed, Israel Vlodavsky, Massimo Iacobelli, Maribel...

https://www.ncbi.nlm.nih.gov/pubmed/30463572 https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1696-z