rabgap1l

RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity Cell-autonomous immunity protects cells by utilizing membrane trafficking to detect and counteract diverse microbial pathogens, including selective autophagy and extracellular expulsion. However, the mechanisms...

Abstract Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk...

From DecodeME Candidate Genes: RABGAP1L (Tier 1) • Protein: RAB GTPase-activating protein 1-like, also known as TBC1D18. UniProt. GeneCards. The allele that increases the risk of ME/CFS is associated with decreasing RABGAP1L gene expression. • Molecular function: GTP-hydrolysis activating...