340 – Monocyte Dysregulation in PASC With Ongoing Pulmonary Symptoms
Thomas K. Awamura, Stefanos Giannakopoulos, Dominic C. Chow, Cecilia M. Shikuma, Gehan Devendra, Vedbar Khadka, Juwon Park
Background
As the number of COVID-19 survivors amongst the global population continues to rise, the...
Proteolethargy is a pathogenic mechanism in chronic disease
Alessandra Dall’Agnese; Ming M. Zheng; Shannon Moreno; Jesse M. Platt; An T. Hoang; Deepti Kannan; Giuseppe Dall’Agnese; Kalon J. Overholt; Ido Sagi; Nancy M. Hannett; Hailey Erb; Olivia Corradin; Arup K. Chakraborty; Tong Ihn Lee...
Inhibition of HIF-2α Pathway as a Potential Therapeutic Strategy for Endothelial Dysfunction in Post-COVID Syndrome
Andrea Ribeiro; Timon Kuchler; Maciej Lech; Javier Carbajo-Lozoya; Kristina Adorjan; Hans Christian Stubbe; Martina Seifert; Anna Wöhnle; Veronika Kesseler; Johanna Negele; Uwe...
Oxidative Stress is a shared characteristic of ME/CFS and Long COVID
Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis
More than 65...
calcium
glutathione
gpx4
lipid droplets
lipids
mark davis
metformin
mitochondria
oxidative stress
reactiveoxygenspecies
ron davis
sex differences
t cells
Abstract
Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis1. Distinct metabolic and mitochondrial features guide the activation and the diverse functional states of myeloid cells2...
Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19
Deepthi Ashok; Ting Liu; Joseph Criscione; Meghana Prakash; Byunggik Kim; Julian Chow; Morgan Craney; Kyriakos Papanicolaou; Agnieszka Sidor; D. Brian Foster; Andrew Pekosz...
Mitochondria and oxygen homeostasis
Mateus P. Mori; Rozhin Penjweini; Jay R. Knutson; Ping-yuan Wang; Paul M. Hwang
Molecular oxygen possesses a dual nature due to its highly reactive free radical property: it is capable of oxidizing metabolic substrates to generate cellular energy, but can...
Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19
Huynh, Tin Van; Rethi, Lekha; Lee, Ting-Wei; Higa, Satoshi; Kao, Yu-Hsun; Chen, Yi-Jen
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to...
Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2
Artem Pliss, Andrey N. Kuzmin, Paras N. Prasad, Supriya D. Mahajan
The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is...
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