sepsis

Deciphering sepsis: transforming diagnosis and treatment through systems immunology Hancock, Robert E. W.; An, Andy; dos Santos, Claudia C.; Lee, Amy H. Y. Sepsis is an abnormal, life-threatening response to infection that leads to (multi-)organ dysfunction and failure. It causes ~20% of deaths...

https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2025.1560472/full The challenge of sepsis Jonathan Cohen* Department of Medicine, Brighton & Sussex Medical School, Brighton, United Kingdom A Viewpoint on the Frontiers in Science Lead Article Deciphering sepsis...

Anecdotal evidence of improvement following anti-fungal treatment As some of your may recall, when Graham McPhee was in hospital with recurrent sepsis, his son @IanMcPhee reported that he had been prescribed anidulafungin (an IV antifungal drug), following which he noticed improvement in his...

The growing crisis of long sepsis. It leaves sufferers with fatigue and brain fog - so when will the NHS start treating it properly? By Lucy Elkins 11:56, 09 Jul 2024, updated 13:09, 09 Jul 2024...

Amyloid-Fibrinogen Aggregates Microclots Predict Risks of Disseminated Intravascular Coagulation and Mortality Schofield, Jeremy; Abrams, Simon Timothy; Jenkins, Rosalind; Lane, Steven; Wang, Guozheng; Toh, Cheng-Hock Microclots have been associated with various conditions, including post-acute...

Blood test that can rapidly identify sepsis being trialled in UK (msn.com)

Abstract We recently demonstrated how sepsis influences the subsequent development of experimental autoimmune encephalomyelitis (EAE) presented a conceptual advance in understanding the postsepsis chronic immunoparalysis state. However, the reverse scenario (autoimmunity prior to sepsis) defines...

David Oliver: Sepsis—what’s behind the “hype”? bmj article: https://www.bmj.com/content/367/bmj.l6327 lancet article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32483-3/fulltext#%20

Paywall, https://link.springer.com/article/10.1007%2Fs10753-019-01081-3 Sci hub, https://sci-hub.se/10.1007/s10753-019-01081-3

In mice. Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0024320519307556 Not currently available on Sci hub.

An interesting blog post. It argues that sepsis and ME/CFS have in common what is called “heterogeneous perfusion”. There is a picture of what that looks like. According to the blog, this would explain many of the characteristics of ME/CFS...

The article, https://phys.org/news/2018-05-lactate-poison.amp The paper, https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30186-4? Full paper here, http://sci-hub.tw/10.1016/j.cmet.2018.03.008

I came across this article from Jan. 2018 http://simmaronresearch.com/2018/01/chronic-fatigue-syndrome-mecfs-chronic-form-sepsis/ about David Bell's idea that ME could be something like a 'slow sepsis'. This topic seems to be a little bit older though...