Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID
Lu Yao; Hannah Devotta; Junhui Li; Nonhlanhla Lunjani; Corinna Sadlier; Aonghus Lavelle; Werner C. Albrich; Jens Walter; Paul W. O’Toole; Liam O’Mahony
Protection against severe...
STING recognition of viral dsDNA by nociceptors mediates pain in mice
https://www.sciencedirect.com/science/article/pii/S0889159124004823
Highlights
Nociceptors can directly sense viral nucleic acids, such as dsDNA derived from herpes and vaccinia viruses.
Cytosolic dsDNA causes nocifensive...
Chloride Homeostasis Regulates cGAS-STING Signaling
Jared Morse; Danna Wang; Serena Mei; Danielle Whitham; Colby Hladun; Costel C. Darie; Herman O Sintim; Modi Wang; KaHo Leung
The cGAS-STING signaling pathway has emerged as a key mediator of inflammation. However, the roles of chloride...
Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α
Queiroz, Maria Alice Freitas; Brito, Wandrey Roberto dos Santos; Pereira, Keise Adrielle Santos; Pereira, Leonn Mendes Soares; Amoras, Ednelza da Silva Graça; Lima, Sandra Souza; Santos, Erika Ferreira...
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