tlr-7

  1. SNT Gatchaman

    [Preprint] Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19, 2025, Kousathanas+

    Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19 In susceptible patients, COVID-19 causes life-threatening disease driven by immune-mediated inflammatory lung injury. We have previously shown that multiple common host genetic variants are...
  2. SNT Gatchaman

    SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes, 2025, Hasler et al.

    SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes SARS-CoV-2 infection is associated with long-lasting neuropsychiatric and cognitive symptoms, collectively referred to as neuro-PASC. Emerging studies indicates that accelerate brain aging and...
  3. SNT Gatchaman

    Cytokine Profile in Patients with Postacute Sequelae of COVID-19, 2024, Ghorra et al.

    Cytokine Profile in Patients with Postacute Sequelae of COVID-19 Nathalie Ghorra; Alexandros Popotas; Tatiana Besse-Hammer; Anne Rogiers; Francis Corazza; Carole Nagant The enduring impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease manifestation, COVID-19...
  4. Andy

    Unique pathways downstream of TLR-4 and TLR-7 activation: sex-dependent behavioural, cytokine, and metabolic consequences 2024 Dunstan et al

    [In mice] Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic...
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