transcriptomics

IFNγ causes mitochondrial dysfunction and oxidative stress in myositis Catalina Abad, Iago Pinal-Fernandez, Clement Guillou, Gwladys Bourdenet, Laurent Drouot, Pascal Cosette, Margherita Giannini, Lea Debrut, Laetitia Jean, Sophie Bernard, Damien Genty, Rachid Zoubairi, Isabelle Remy-Jouet...

COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID Soneida DeLine-Caballero; Kalani Ratnasiri; Heping Chen; Seynt Jiro Sahagun; Uma M. Mangalanathan; Trisha R. Barnard; Nicole Turk; Jasmine Yang; Natesh Saini; Ekrem M. Ayhan; Hasiyet...

Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection Silvia Lucena Lage; Katherine Bricker-Holt; Joseph M. Rocco; Adam Rupert; Frank X. Donovan; Yevgeniya A. Abramzon; Settara C. Chandrasekharappa; Colton McNinch; Logan Cook; Eduardo Pinheiro Amaral; Gabriel...

Abstract Gulf War Illness (GWI) is a multi-symptom disorder affecting 1990–1991 Persian Gulf War veterans and is characterized by post-exertional malaise, neurological symptoms, immune deregulation, and exhaustion. Causation is not understood, and effective diagnostics and therapies have not yet...

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space Moreno-Villanueva, Maria; Jimenez-Chavez, Luis E.; Krieger, Stephanie; Ding, Liang-Hao; Zhang, Ye; Babiak-Vazquez, Adriana; Berres, Mark; Splinter...

Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition Vollger, Mitchell R.; Korlach, Jonas; Eldred, Kiara C.; Swanson, Elliott; Underwood, Jason G.; Bohaczuk, Stephanie C.; Mao, Yizi; Cheng, Yong-Han H.; Ranchalis, Jane; Blue, Elizabeth E...

A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals Missailidis, Daniel; Ebrahimie, Esmaeil; Mohammadi-Dehcheshmeh, Manijeh; Allan, Claire; Sanislav, Oana; Fisher, Paul Robert; Gras, Stephanie; Annesley, Sarah Jane Long COVID is a debilitating condition...

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients Shahbaz; Rezaeifar; Syed; Redmond; Terveart; Osman; Elahi A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications...

Abstract Neuroimaging studies have indicated that altered cerebral blood flow (CBF) was associated with the long-term symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), also known as “long COVID”. COVID-19 and long COVID were found to be strongly associated with host gene expression...

Differential Gene Expression in the Upper Respiratory Tract following Acute COVID-19 Infection in Ambulatory Patients That Develop Long COVID Biondi, Mia J.; Addo, Mary; Zahoor, Muhammad Atif; Salvant, Elsa; Yip, Paul; Barber, Bethany; Smookler, David; Wasif, Sumaiyah; Gaete, Kayla; Kandel...

Abstract Background Months after infection with SARS-CoV-2, at least 10% of patients still experience complaints. Long-COVID is a heterogeneous disease and clustering efforts revealed multiple phenotypes on a clinical level. However, the molecular pathways underlying long-COVID phenotypes are...

Gut permeability among Astronauts during Space missions Akinsuyi; Xhumari; Ojeda; Roesch The space environment poses substantial challenges to human physiology, including potential disruptions in gastrointestinal health. Gut permeability has only recently become widely acknowledged for its...

Towards understanding post-COVID-19 condition: A systematic meta-analysis of transcriptomic alterations with sex-specific insights Rusu; Monfort-Lanzas; Bertran; Barrientos-Riosalido; Solé; Mahmoudian; Aguilar; Briansó; Mohamed; Garcia; Camaron; Auguet BACKGROUND Post COVID-19 Condition (PCC)...

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome T. Pietrangelo; R. Mancinelli; L. Toniolo; G. Montanari; J. Vecchiet; G. Fanò; S. Fulle Chronic fatigue syndrome (CFS) is a disabling condition characterized by unexplained chronic fatigue that...

The Acute, Short-, and Long-Term Effects of Endurance Exercise on Skeletal Muscle Transcriptome Profiles Beiter, Thomas; Zügel, Martina; Hudemann, Jens; Schild, Marius; Fragasso, Annunziata; Burgstahler, Christof; Krüger, Karsten; Mooren, Frank C.; Steinacker, Jürgen M.; Nieß, Andreas M. A...

Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight Anurag Sakharkar; Kiven Erique Lukong; Lauren M Sanders; Sylvain V Costes; Jian Yang; Changiz Taghibiglou Space exploration has captured the imagination of humanity for generations. From the first steps on the moon to...

Published as a preprint. See post #7 And now published in final form - link here ****** This is an abstract from the Demystifying Long COVID International Conference 2023, converted from an image on Twitter, so it might be slightly wonky, but it looks intriguing. Blood Transcriptomics Reveal...

The Human Microglia Atlas HuMicA Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions Ricardo Martins-Ferreira; Josep Calafell-Segura; Barbara Leal; Javier Rodriguez-Ubreva; Elisabetta Mereu; Paulo Pinho e Costa; Esteban Ballestar...

Full title: Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multi-symptom illness characterized by debilitating...

Preprint https://www.biorxiv.org/content/10.1101/2022.10.13.512091v1 SUMMARY ME/CFS is a serious and poorly understood disease. To understand immune dysregulation in ME/CFS, we used single-cell RNA-seq (scRNA-seq) to examine immune cells in cohorts of patients and controls. Post-exertional...