tspo

Abstract Background: This study examined the regional distribution of glial activation in essential workers with neurological post-acute sequelae of coronavirus disease 2019 (COVID-19) infections (N-PASC). Methods: We injected ≤185 MBq of [18F]-FEPPA as an intravenous bolus and...

Published version linked in this later post here Preprint Abstract The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent...

Distinct molecular profiles of skull bone marrow in health and neurological disorders Zeynep Ilgin Kolabas; Louis B. Kuemmerle; Robert Perneczky; Benjamin Förstera; Selin Ulukaya; Mayar Ali; Saketh Kapoor; Laura M. Bartos; Maren Büttner; Ozum Sehnaz Caliskan; Zhouyi Rong; Hongcheng Mai; Luciano...

Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques Nieuwland, Juliana M.; Nutma, Erik; Philippens, Ingrid H. C. H. M.; Böszörményi, Kinga P.; Remarque, Edmond J.; Bakker, Jaco; Meijer, Lisette; Woerdman...

Published version linked in a later post ***** Preprint Choroid Plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study Tracy Butler, X. Hugh Wang, Gloria C. Chiang, Yi Li, Liangdong Zhou, Ke Xi, NimmiWickramasuriya, Emily Tanzi, Edward...

Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET (Preprint) Denise Visser, Sandeep S.V. Golla, Sander C.J. Verfaillie, Emma M. Coomans, Roos M. Rikken, Elsmarieke M. van de Giessen, Marijke E. den Hollander, Anouk Verveen, Maqsood Yaqub, Frederik Barkhof...

Brief Summary: The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with...

Given that there is anecdotal evidence of lorazepam (Ativan) causing rapid temporary improvement of ME symptoms, even in very severe cases, I’ve wondered why ME researchers aren’t looking more closely at researching selective translocator protein (TSPO) agonists. TSPO is also known as the...