Enhanced sensitivity of the peripheral cholinergic vascular response in patients with chronic fatigue syndrome
Vance A Spence; Faisel Khan; Jill J.F Belch
Patients with chronic fatigue syndrome have a variety of clinical symptoms, with associated physical, psychological, and social disability...
Significance
ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain undefined. In this study, we identify primary ChAT+ T cells in patients...
Abstract
Vaso-occlusive crisis (VOC) is a hallmark of sickle cell disease (SCD) and occurs when deoxygenated sickled red blood cells occlude the microvasculature. Any stimulus, such as mental stress, which decreases microvascular blood flow will increase the likelihood of red cell entrapment...
Abstract
Chronic Fatigue Syndrome or Myalgic Encephaloymelitis (ME/CFS) is a frequent debilitating disease with an enigmatic etiology. The finding of autoantibodies against ß2-adrenergic receptors (ß2AdR) prompted us to hypothesize that ß2AdR dysfunction is of critical importance in the...
Read more: https://www.hindawi.com/journals/mi/2008/792428/
This is an old-ish study, bit has some interesting ideas about neurological conditions. Though it doesn't mention ME directly, three of the references used to support the argument deal with 'CFS'. The theory goes that interrupted VNs...
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