Exploring Hypercoagulability in Post-COVID Syndrome PCS: An Attempt at Unraveling the Endothelial Dysfunction
Muys, Maxim; Demulder, Anne; Besse-Hammer, Tatiana; Ghorra, Nathalie; Rozen, Laurence
BACKGROUND
The lingering effects of SARS-CoV-2 infection, collectively known as post-COVID syndrome...
Stefania Bellone, Eric R. Siegel, David E. Scheim, Alessandro D. Santin
Highlights
Growing evidence suggests that persistent microvascular inflammation, clumping/clotting of blood cells and thrombotic complications may be key causes of Long COVID.
Plasma levels of von Willebrand factor and...
Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?
Gerencer, Marijan; McGuffin, Liam J.
The previous studies on the RGD motif (aa403-405) within the SARS CoV-2 spike (S) protein receptor binding domain (RBD) suggest that...
Molecular Analysis of SARS-CoV-2 Spike Protein-Induced Endothelial Cell Permeability and vWF Secretion
Guo, Yuexi; Kanamarlapudi, Venkateswarlu
Coronavirus disease COVID-19, which is caused by severe acute respiratory syndrome coronavirus SARS-CoV-2, has become a worldwide pandemic in recent...
Abstract
Background
Prolonged recovery is common after SARs-CoV-2 infection, however the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF-ADAMTS13 imbalance, dysregulated angiogenesis and immuno-thrombosis are hallmarks of acute COVID-19. We hypothesized that...
Abstract
Background
Persistent symptoms including breathlessness, fatigue and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this ‘Long COVID’ syndrome remain unknown. However, autopsy studies have highlighted...
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