1. A diabetes drug for Parkinson's disease 2. ADC for ovarian cancer 3. CRISPR-Cas9 for muscular dystrophy 4. Cervical cancer screening in the vaccinated 5. The Mediterranean diet for weight loss 6. Safe treatment for sleeping sickness 7. Circulating tumor cells 8. Lecanemab for Alzheimer's disease 9. COVID-19 vaccination and HIV 10. Gene editing for sickle-cell disease 11. Reducing harm for prostate cancer screening https://www.nature.com/articles/s41591-022-02132-3
Thanks for posting this. I had no idea about using exenatide for Parkinson’s—Some speculation on mechanism here https://bmjopen.bmj.com/content/bmjopen/11/5/e047993.full.pdf
Re 11, and as far as I can see from my own experience and quite a bit of googling, UK prostate pathways seem perfectly sensible already: PSA tests and the arsefinger probe may raise clinical suspicion, but multi-parametric MRIs are the first port of call before any invasive biopsies are carried out, and watchful waiting or active surveillance are preferred to radical options unless there is good reason. It’s only in the US that testing and biopsies seem to be ubiquitous.
https://bmjopen.bmj.com/content/bmjopen/11/5/e047993.full.pdf PI here Thomas Foltynie is from UCL. @Jonathan Edwards any chance you know him? If yes, I’m curious to know if they believe that exenatide in particular has positive neuro effects or whether they believe that all GLP1 agonists would also have beneficial neurological effects. Thanks.
