A cluster analysis of serious adverse event reports after (HPV) vaccination in Danish girls and young women, Sept 2009 to Aug 2017, 2019, Ward et al

Andy · May 16, 2019

Background
Suspected adverse events (AE) after human papillomavirus (HPV) vaccines include postural orthostatic tachycardia syndrome (POTS), chronic fatigue syndrome (CFS), complex regional pain syndrome (CRPS) and symptoms including headache and orthostatic intolerance.

Aim
We aimed to identify phenotypes of AEs after HPV vaccination, defined as patterns of AE terms (signs, symptoms, diagnoses), and to evaluate if identified phenotypes reflected previously suspected symptomatology or heightened public concerns over HPV vaccine safety since 1 January 2015.

Methods
We conducted a retrospective observational study using latent class cluster analysis of all serious AE reports (n = 963) reported by females residing in Denmark between September 2009 and August 2017. Resulting clusters were characterised according to AE terms associated with POTS, CFS and CRPS before (September 2009–December 2014) and during (January 2015–August 2017) a time of heightened media activity regarding HPV vaccines.

Results
Four clusters of AE reports were distinguished. The most common symptoms were fatigue, dizziness and headache but their frequency varied among clusters. The majority of reports in one cluster were submitted during a period of heightened media activity, including an anomalous spike in submissions in December 2015; a high proportion of these reports included the symptoms cognitive disorder (78%), abdominal pain (77%), dysuria (60%) and sleep disorder (60%).

Conclusions
Non-specific symptoms including headache, fatigue and dizziness feature prominently in serious AE reports from females in Denmark. Our analysis identified a cluster of reports, likely media stimulated, with a focus on symptoms of CFS and POTS.
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Open access, https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.19.1800380#html_fulltext

ScottTriGuy · May 16, 2019

"...Our analysis identified a cluster of reports, likely media stimulated, with a focus on symptoms of CFS and POTS."

Are they saying that these reported adverse reactions post HPV vaccine was just media caused hysteria among females?

pteropus · May 16, 2019

nice use of subjective questions, without objective measurements, and emotional attribution, to vanish a problem.

Amw66 · May 16, 2019

perhaps to counter Geotzsche?

rvallee · May 16, 2019

ScottTriGuy said: ↑

"...Our analysis identified a cluster of reports, likely media stimulated, with a focus on symptoms of CFS and POTS."

Are they saying that these reported adverse reactions post HPV vaccine was just media caused hysteria among females?
Click to expand...

Controversial opinion but I prefer it when science avoids wild speculation on implausible explanations.

Hypothesizing is fine but this is clearly an ideological slant with no credible basis.

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A cluster analysis of serious adverse event reports after (HPV) vaccination in Danish girls and young women, Sept 2009 to Aug 2017, 2019, Ward et al

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A cluster analysis of serious adverse event reports after (HPV) vaccination in Danish girls and young women, Sept 2009 to Aug 2017, 2019, Ward et al

Andy Committee Member

ScottTriGuy Senior Member (Voting Rights)

pteropus Senior Member (Voting Rights)

Amw66 Senior Member (Voting Rights)

rvallee Senior Member (Voting Rights)

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