A Multimodal Ayurveda and Mind–Body Therapeutic Intervention for ... Postinfectious Syndrome: A Pilot Study, 2023, Shere-Wolfe et al

https://www.researchgate.net/public...ed_to_a_Postinfectious_Syndrome_A_Pilot_Study

Abstract
Objective: Evaluate feasibility and impact of a multimodal integrative therapeutic intervention in patients presenting with chronic symptoms attributed to a postinfectious syndrome.

Design: This was a prospective longitudinal single-center pilot study conducted from January 2019 to December 2020.

Setting/Location: University of Maryland Lyme Program, Baltimore Maryland.

Subjects: Persons presenting for Lyme evaluation for symptoms attributed to Lyme disease.

Interventions: Participants attended two 1-h individual instructional sessions consisting of Ayurveda-based dietary intervention and breath-coordinated mind-body practice to be used for home practice.

Outcome measures: Standard measures of impact were obtained at baseline, 1, 3, 6, and 12 months using the following validated survey instruments: Perceived Stress Scale (PSS), PROMIS Global Health v1.2 (GH), and PROMIS 29 v2.0 survey.

Results: From 216 patients presenting for Lyme evaluation, 19 participants enrolled with 84% completing the study (N = 16). Baseline PROMIS GH scores consisting of general Physical Health (GPH) and general Mental Health (GMH) scores were lower in the study population than in the general U.S. population. PROMIS 29 scores were higher for fatigue, anxiety, and pain than those in the general U.S. population. Over 12-month period, improvement in both the GPH and GMH was 6.09 (confidence interval [95% CI] = 2.71–9.46; p < 0.001) and 4.65 (95% CI = 1.50–7.80; p = 0.004), respectively. PROMIS 29 scores showed the greatest improvement in fatigue at −7.91 (95% CI = −12.34 to −3.48; p < 0.001), pain interference −5.08 (95% CI = −9.20 to −0.96; p = 0.016), and ability to participate in social roles and activities 7.48 (95% CI = 3.21–11.75; p = 0.001) and least with depression −1.82 (95% CI = −4.74 to 1.10; p = 0.223). Employment status had significant effects on almost all outcome scores. Postinfectious state was associated with improvement in anxiety and PSS scores.

Conclusions: A multimodal Ayurvedic and breath-coordinated mind–body therapeutic intervention is feasible and a potential nonpharmacologic therapeutic option for persons presenting with pain, stress, fatigue, physical dysfunction, and sleep disturbance attributed to a postinfectious syndrome. Further research is needed to determine efficacy in this population and in other groups with similar symptom complexes due to postinfectious syndromes.

 

The natural outcome of the biopsychosocial model and its constant need to degrade and lower the quality of evidence.

You could use this model to prove that drinking cow urine is good. It's what it's for: to prove anything you want. You just have to try it again and again and again until you get some result you like.

I really need to say this again and again but randomized clinical trials are the least reliable and most biased form of evidence used by professionals. Ever. They are simply not good, and basically represent the absurd combination of failing at all 3 angles of the project management triangle: cost, speed, quality. It's literally the worst possible way of doing things on all 3, and if medicine wants to get serious about making progress, they need to develop better methodologies than this unreliable crap.