A Proposal for Explaining Progression from Light/Moderate to Severe Chronic Fatigue, 2020, Höck

Free full text:
https://escientificlibrary.com/nutritional-health/Article/ESJNH-V1-1008.pdf

 

Sigh. Who's volunteering to explain that 'highly protective sunscreen' didn't exist in the 1960s and 70s, and the redheads among us have the skin cancers to prove it?

And that vitamin D deficiency is a bit unlikely in people who'd spent every possible moment mucking about outdoors as kids, and enjoyed cheap activities like hiking, cycling, and camping right up to becoming ill, because almost nobody had a family car back then?

I'm not even going to start on personality and stress...

 

My GP has regularly checked my vitamins levels, and surely for most doctors checking vitamins should be part of the routine tests used to exclude other possibilities when diagnosing ME. So I think if vitamin D deficiency was an issue then it would be diagnosed more frequently.

The only vitamin related issue that consistently has shown up for me is B12 deficiency.

Presumably the author would predict lower incidences of severe ME in people who spend more time outside or who live in sunnier countries, which I suspect is not necessarily the case.

[added - my very subjective recollections of periods of deterioration in my ME is that they are more likely to occur after periods of more time spent active outdoors. My current four years or so of being largely bed bound followed an active summer with time spent gardening, camping, walking and visits to the beach.]

 

It seems to be saying that it begins as 'simple' deficiency due to use of highly effective sunscreens and the predominance of indoor activities, and this is the point at which it needs to be addressed. Once ME kicks in it may become Vitamin D resistance, and supplementing may not be enough to overcome it.

The theory doesn't allow for the fact that young people developed ME long before working sunscreens were developed, and when children or teenagers spending a lot of time indoors really couldn't be further from the norm.

[Edited out superfluous word.]

 

I know the person is in nutrition science and this is not the point of the research but people who like to be thought of as doing science need to stop saying 'mere psychiatric'.

Consultation-liaison psychiatry is a joke but other psychiatrists work with people who have pyschoses, bi-polar, schizophrenia etc. They are not 'mere' and people with ME do not talk that way about these illnesses (although I don't think that was implied).

Just a small off topic complaint. We shouldn't see this kind of wording in science.

Also, 'specific personality traits'? With regards to being indoors or not, I don't think personality is the main consideration. Lots to unpack there.

I wish there was more science done on understanding the function of things biologically including Vit D. But I think studying that apart from making theories as to specifics in a disease is a better place to start and then one can form better theories about specifics. I don't think we know enough yet.

The lattitude thing could be examined with a prevalence study though maybe? MS is apparently higher in Canada then elsewhere (for example).

 

Hmm. I have had vitD deficiency. I probably have it now because I do not tolerate supplementing D3...

 

Shockingly 'fixing' vitamin D status did not cure my ME, or anything else, and it was pretty low - and the process was at times excruciating.

 

I read a similar theory in a book about Testosterone resistance. The theory is that your levels are within normal standard ranges but your body has a resistance to it, so some people need to supplement.
http://www.testosteronedeficiency.org/testosterone-resistance-by-prof-mc

I personally knew a gentleman who saw Dr Carruthers once a year to renew a prescription for testosterone replacement therapy and he felt that led him to a normal life, with a varied career such as doctor, researcher, and finally VP of R&D at a major pharmaceutical. He is long retired. Without it he would not have been able to continue on his career path and have a successful career as the fatigue without it was crushing.

He told me about this story when he heard about my ME progressing, and how there is still so much to learn about how the human body works. So yes, perhaps there is such a thing as vitamin D resistance, but it will be very difficult to prove.

Note : this story involved more than just bound and unbound (free) Testosterone I think, but that may have been part of it as well for some folks.

 

An interesting read
https://mpkb.org/home/publications/albert_autoimmunity_reviews_2009

 

Disease of the gut, such a Celiac disease, Chron's disease and chronic ulcerative colitis, can apparently interfere with the absorption of nutrients, including vitamin D. https://www.healthline.com/health/malabsorption

My impression is IBS and IBD may be more common in ME/CFS than in the general population (and might go unrecognized), so that might explain some of the vitamin deficiencies seen.

 

As can changes to gut PH due to medication / bacterial dysbiosis.

 

While I don't find this hypothesis overly convincing it should be able to be easily tested. Do large numbers of vit D tests on people testing positive for corona and check in with them again 6 months later. If those with good vit D levels recovered quickly and those with deficiencies are starting to get ME diagnoses the whole thing would be worth looking at in more depth. Until then I suspect it's more likely those of us with low vit D have a deficiency as a result of ME rather than as a cause.

 

There are genetic SNPs at VDR genes which affect the ability to absorb/ synthesize/ process vitamin D

 

Magnesium assists in the activation of vitamin D. Once I increased Mg levels through injections, my vitamin D went up without supplementing.

 

Vitamin K2 (don't remember which type, think it was the longer lasting one) helped with the joint and other pain, allegedly cursed by the 'mobilisation' of something or other.

But as I said, I raised my levels from '11' (of whatever the UK units are - test said anything below 25 was sub range normal was a lot more) and it didn't, as far as I remember, make much difference to anything

 

I've been taking vitamin K2 MK-7 (from Natto) for almost 2 years, it has greater bioavailability than MK-4. I would have liked to have had a bone scan before and after to see if my bones are stronger.

 

I haven't noticed any relationship between vitamin D3 levels and symptoms (and summer vs winter, or during supplementation), and I see from replies that I'm not the only one...