A Systematic Analysis of the Effectiveness of Mitochondrial-Based Therapies for the Management of (ME/CFS), 2023, Keferstein

A Systematic Analysis of the Effectiveness of Mitochondrial-Based Therapies for the Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)



Abstract
Background: This study aimed to compile and analyze an assortment of research findings concerning potential therapeutic strategies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The understanding of the multifaceted nature of ME/CFS and the need for varied and personalized therapeutic approaches were central to this investigation.

Methods: A comprehensive review and analysis of various studies conducted on ME/CFS was undertaken. These studies covered a wide array of interventions, including pharmacological treatments, nutritional supplements, dietary changes, physical therapies, and lifestyle modifications. The analysis pertained to the effectiveness of these interventions, potential physiological and biochemical markers, and the response of ME/CFS patients to different treatment strategies.

Results: The 22 selected papers investigated demonstrated varied responses to the multitude of interventions. While some interventions showed significant improvement in fatigue and biochemical parameters, others found no significant differences between the treated and control groups. Potential physiological and biochemical markers for ME/CFS, such as impaired T cell metabolism, reduced flow-mediated dilation, and decreased work rate at the ventilatory threshold, were highlighted.

Conclusion: The findings underscored the complexity of ME/CFS and the need for personalized treatment strategies. Despite mixed results and several limitations, these studies collectively contributed to understanding ME/CFS's complex pathophysiology and treatment, laying the groundwork for future research towards more effective therapeutic strategies for this debilitating disease.

https://www.preprints.org/manuscript/202310.0637/v1

 

I haven't looked at it yet, but there seems to be a conflict between the title and the abstract. The title is 'A Systematic Analysis of the Effectiveness of Mitochondrial-Based Therapies', but the abstract doesn't mention mitochondria at all.

 

In other words: "Some treatments work for a few PWME, but we don't know in advance which ones will work for which people, or why they work (or don't work)."

Oh, it's a review of studies, so: "Some studies show positive results from some treatments, and others don't show positive results." Are they expecting some sort of award for this great contribution to the understanding of ME?

 

On Gerrit Keferstein (translated):

"Through his intensive self-study with literature, further education, networking and exchange, he came across an elementary explanation of previously unknown connections between environmental influences and chronic diseases: Mitochondrial energy production. This is currently leading to a profound paradigm shift in prevention, diagnostics and treatment."

"As a medical doctor specialising in chronic diseases, I help my clients and patients to regain their strength and full regenerative capacity quickly and sustainably."

https://mojo-institut.de/gerrit-keferstein/

He has a large online presence and is active on Instagram, Youtube and Twitter (where he propagates Ivermectin for the removal of the spike protein in Long-Covid www.twitter.com/mitodoc/status/1694087350551232545). I'll leave it at that.

 

It's advertising.

I'd be having fun writing parodies of this stuff and submitting them as preprints, if the energy were available.