A triple drug combination targeting components of the nutrient-sensing network maximizes longevity Quan et al. 2019

So it turns out the person who was highlighted on the Cort Johnson blog as being in remission from rapamune was ALSO taking lithium…..

https://www.pnas.org/doi/10.1073/pnas.1913212116

Abstract
Increasing life expectancy is causing the prevalence of age-related diseases to rise, and there is an urgent need for new strategies to improve health at older ages. Reduced activity of insulin/insulin-like growth factor signaling (IIS) and mechanistic target of rapamycin (mTOR) nutrient-sensing signaling network can extend lifespan and improve health during aging in diverse organisms. However, the extensive feedback in this network and adverse side effects of inhibition imply that simultaneous targeting of specific effectors in the network may most effectively combat the effects of aging. We show that the mitogen-activated protein kinase kinase (MEK) inhibitor trametinib, the mTOR complex 1 (mTORC1) inhibitor rapamycin, and the glycogen synthase kinase-3 (GSK-3) inhibitor lithium act additively to increase longevity in Drosophila. Remarkably, the triple drug combination increased lifespan by 48%. Furthermore, the combination of lithium with rapamycin cancelled the latter’s effects on lipid metabolism. In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health.

 

So, we can, again, produce longer lived fruit flies.

I'm not sure how that helps anyone, other than researchers into the lifespan of fruit flies.

For people the obvious, and cheap, way of reducing the prevalence of age-related diseases is to reduce the prevalence of old age, possibly by reducing the value of pensions, or by increasing stress, by repeatedly flip flopping/dithering over such issues.

But possibly ethical issues in doing that sort of research, but not in actually doing it or so it seems, so we have...


...fruit flies.

 

See comment from Jeremy Waletzky on August 4th at the bottom of the comment section.

https://www.healthrising.org/blog/2022/07/06/apamycin-resurgence-doctor-chronic-fatigue-syndrome/

 

https://academic.oup.com/hmg/article/17/2/170/589691

https://www.nature.com/articles/ncpneuro0679

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin

Enhances autophagy!

Which links back to here!! https://www.s4me.info/threads/eleva...microglial-cells-2022-gottschalk-et-al.27343/