Adverse effects following...vaccination with mRNA...correlate with baseline enrichment of T and NK cell genes, 2022, Syenina et al

Full title: Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes, Ayesa Syenina et al (PLOS 2022)

T and NK cell correlation - humans
route of vaccine administration - mice

Open access: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001643

 

Are there no ways to intentionally modulate this type of gene expression? Some drugs, cellular isolates, nutrients or whatever? I can imagine giving a test subject doses of various things, and one of them resulting in the patient saying "Wow, I feel healthy again." Even one that gives a reliable "Ohhh, I feel horrible." response would be useful for identifying the responsible pathway.

 

i cannot read article. going by the quotes onlly here are they looking at fatigue in mice in addition to vaccine ae?

 

Haven't read it yet either but yes, the bit on vaccine administration route was on mice. However, the part about baseline enrichment of T and NK cell genes correlating with adverse effects was on people.