Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently . . . ethnicity:A cross-sectional study

Mij · Jun 2, 2024

Key Points

While today marks the end of Sunshine Month, it is important to remember and implement the key points provided about sensible sunshine exposure for our health year-round

A newly released study (April 2024) used data from half a million participants from the United Kingdom (UK,) to calculate the individualized estimate of ambient ultraviolet-B (UVB) level, which is the wavelength of sunlight that induces vitamin D synthesis in the skin

They found two major insights from the data: 1. That ambient UVB emerges as a critical predictor of vitamin D status, even in a place like the UK, which receives relatively little sunlight; 2. Age, sex, body mass index (BMI), cholesterol level, and vitamin D supplementation significantly influence how individuals respond to UVB

Ambient ultra-B radiation, supplements and other factor interact to impact vit D status differently depending on ethnicity: A cross-sectional study, 2024, Margaret M Brennen et al

Summary
Background & aims
Many determinants of vitamin D status have been well-described, yet supplementation guidelines largely follow a one-size-for-all model and deficiency remains common. We hypothesised that accounting accurately for ultraviolet-B (UVB) radiation and considering interactions could advance understanding of vitamin D status.
Methods
Asian, Black, and White participants from the UK Biobank cohort were included (N = 438,978). The Tropospheric Emission Monitoring Internet Service provided UVB data which we linked to participants' place of residence. UVB dose over 135 days prior to blood draw was weighted and added, yielding cumulative and weighted UVB (CW-D-UVB). The association between 25(OH)D and selected variables was assessed in multivariable linear regression models with and without interactions, stratified by ethnicity. Predictors were ranked using standardised β-coefficients.
Results
Median 25(OH)D differed by ethnicity (Asian: 25.4 nmol/L (10.2 ng/mL), Black: 30.6 nmol/L (12.2 ng/mL), White: 47.9 nmol/L (19.2 ng/mL), p-value < 0.001). CW-D-UVB was strongly associated with 25(OH)D in all ethnicities. It was the most important predictor in White (βAsian = 0.15, βBlack = 0.20, βWhite = 0.35), whereas supplementation was in Asian and Black participants (βAsian = 0.30, βBlack = 0.24, βWhite = 0.21). We identified statistically significant interactions between BMI:supplementation (all), CW-D-UVB:sex (Asian and White), and CW-D-UVB:age (Black and White), and in White population between CW-D-UVB and supplementation, BMI, and cholesterol.
Conclusion
Vitamin D deficiency was widespread, particularly among non-White individuals. UVB was a strong predictor of 25(OH)D and the effect was modified by other factors. Findings suggest that accurately measured ambient-UVB radiation and interactions could improve 25(OH)D prediction models, and support personalised approaches to vitamin D optimisation.
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Mij · Jun 2, 2024

Study Illustrates Influence of Ethnicity, BMI, and Age on How Vitamin D Levels Respond to UVB Exposure

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Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently . . . ethnicity:A cross-sectional study

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Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently . . . ethnicity:A cross-sectional study

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